PMID- 25933632 OWN - NLM STAT- MEDLINE DCOM- 20160628 LR - 20221207 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 25 IP - 12 DP - 2015 Dec TI - Diabetes Associated Markers After Bariatric Surgery: Fetuin-A, but Not Matrix Metalloproteinase-7, Is Reduced. PG - 2328-34 LID - 10.1007/s11695-015-1688-5 [doi] AB - BACKGROUND: Recent studies showed that fetuin-A and matrix metalloproteinase-7 (MMP-7) are type 2 diabetes mellitus (T2DM)-associated markers. Bariatric surgery not only reduces body weight but also improves T2DM. This study aimed to investigate the changes of fetuin-A and MMP-7 in obese subjects with and without T2DM after bariatric surgery. METHODS: We enrolled 130 obese subjects that received bariatric surgery, including 41 Roux-en-Y gastric bypass (RYGB), 67 mini-gastric bypass (MGB), and 22 sleeve gastrectomy (SG) patients. Forty-three patients suffered from T2DM prior to surgery. The fasting serum fetuin-A and MMP-7 levels were measured before and 1 year after surgery. RESULTS: Only five of 43 patients remained diabetic after surgery. Preoperative T2DM patients had higher fetuin-A and MMP-7 levels than non-T2DM subjects. RYGB, MGB, and SG all decreased the fetuin-A levels 1 year after the operation. The MMP-7 levels were not changed after RYGB, MGB, or SG. In multivariate analyses, the preoperative fetuin-A was significantly related to the diastolic blood pressure (DBP) and glycosylated hemoglobin (HbA1c), while the postoperative fetuin-A was independently related to the waist-to-hip ratio and HbA1c. Moreover, the preoperative MMP-7 level was significantly related to age, DBP, aspartate transaminase, alanine transaminase, and gamma-glutamyl transferase (rGT), while the postoperative MMP-7 level was independently related to age and rGT. CONCLUSIONS: The fetuin-A and MMP-7 levels are both higher in obese T2DM than non-T2DM subjects. The level of fetuin-A is reduced after RYGB, MGB, and SG, but the level of MMP-7 remains unchanged. FAU - Yang, Po-Jen AU - Yang PJ AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. paulpjyang@yahoo.com.tw. AD - Department of Surgery, National Taiwan University Hospital Jin-Shan Branch, New Taipei City, Taiwan. paulpjyang@yahoo.com.tw. AD - Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. paulpjyang@yahoo.com.tw. FAU - Ser, Kong-Han AU - Ser KH AD - Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan. maxist_ser@hotmail.com. FAU - Lin, Ming-Tsan AU - Lin MT AD - Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. linmt@ntu.edu.tw. FAU - Nien, Hsiao-Ching AU - Nien HC AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. celian0916@yahoo.com.tw. AD - Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan. celian0916@yahoo.com.tw. FAU - Chen, Chiung-Nien AU - Chen CN AD - Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. cnchen@ntu.edu.tw. FAU - Yang, Wei-Shiung AU - Yang WS AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. wsyang@ntu.edu.tw. AD - Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. wsyang@ntu.edu.tw. FAU - Lee, Wei-Jei AU - Lee WJ AD - Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan. wjlee_obessurg_tw@yahoo.com.tw. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 RN - 0 (AHSG protein, human) RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (alpha-2-HS-Glycoprotein) RN - EC 3.4.24.23 (MMP7 protein, human) RN - EC 3.4.24.23 (Matrix Metalloproteinase 7) SB - IM MH - Adult MH - Aged MH - *Bariatric Surgery/rehabilitation MH - Biomarkers/analysis/blood MH - Diabetes Mellitus, Type 2/blood/complications/*surgery MH - Down-Regulation MH - Fasting/blood MH - Female MH - Glycated Hemoglobin/analysis/metabolism MH - Humans MH - Male MH - Matrix Metalloproteinase 7/analysis/*blood MH - Middle Aged MH - Obesity/blood/complications/*surgery MH - Postoperative Period MH - Waist-Hip Ratio MH - Weight Loss MH - alpha-2-HS-Glycoprotein/analysis/*metabolism OTO - NOTNLM OT - Bariatric surgery OT - Diabetes OT - Fetuin-A OT - MMP-7 OT - Obesity EDAT- 2015/05/03 06:00 MHDA- 2016/06/29 06:00 CRDT- 2015/05/03 06:00 PHST- 2015/05/03 06:00 [entrez] PHST- 2015/05/03 06:00 [pubmed] PHST- 2016/06/29 06:00 [medline] AID - 10.1007/s11695-015-1688-5 [pii] AID - 10.1007/s11695-015-1688-5 [doi] PST - ppublish SO - Obes Surg. 2015 Dec;25(12):2328-34. doi: 10.1007/s11695-015-1688-5.