PMID- 25934190 OWN - NLM STAT- MEDLINE DCOM- 20150812 LR - 20150608 IS - 1879-0038 (Electronic) IS - 0378-1119 (Linking) VI - 567 IP - 2 DP - 2015 Aug 10 TI - Examination of the brain natriuretic peptide rs198389 single-nucleotide polymorphism on type 2 diabetes mellitus and related phenotypes in an Algerian population. PG - 159-63 LID - S0378-1119(15)00515-6 [pii] LID - 10.1016/j.gene.2015.04.073 [doi] AB - BACKGROUND: In European populations, the NPPB rs198389 single nucleotide polymorphism (SNP) is associated with a reduced risk of type 2 diabetes mellitus (T2DM). We investigated the putative associations between NPPB rs198389, the T2DM risk and quantitative metabolic traits in an Algerian population. METHODS: The association analysis was performed as a T2DM case-control study (with 78 cases and 645 controls) nested into the ISOR population-based study. RESULTS: The NPPB rs198389 SNP was not associated with T2DM (odds ratio (OR) [95% confidence interval (CI)]=0.73 [0.51-1.04], p=0.08). However, the C allele was associated with lower fasting plasma insulin levels (p=0.05) and a lower homeostatic model assessment insulin resistance index (p=0.05) in non-diabetic individuals. CONCLUSION: The NPPB rs198389 SNP might modulate fasting insulin levels in an Algerian population. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Meroufel, Djabaria Naima AU - Meroufel DN AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria. Electronic address: meroufeln@yahoo.fr. FAU - Ouhaibi-Djellouli, Hadjira AU - Ouhaibi-Djellouli H AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria; Departement de Biotechnologie, Faculte des Sciences de la Nature et de la Vie, Universite d'Oran, BP 1524, El M'Naouer, 31000 Oran, Algeria. Electronic address: djellouli.ouhaibi@gmail.com. FAU - Mediene-Benchekor, Sounnia AU - Mediene-Benchekor S AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria; Departement de Biotechnologie, Faculte des Sciences de la Nature et de la Vie, Universite d'Oran, BP 1524, El M'Naouer, 31000 Oran, Algeria. Electronic address: sonia_mediene@yahoo.fr. FAU - Hermant, Xavier AU - Hermant X AD - INSERM, U1167, Institut Pasteur de Lille, Universite de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille cedex, France. Electronic address: Xavier.Hermant@pasteur-lille.fr. FAU - Grenier-Boley, Benjamin AU - Grenier-Boley B AD - INSERM, U1167, Institut Pasteur de Lille, Universite de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille cedex, France. Electronic address: Benjamin.Grenier-Boley@pasteur-lille.fr. FAU - Lardjam-Hetraf, Sarah Aicha AU - Lardjam-Hetraf SA AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria. Electronic address: lardjamhetraf_sarah@yahoo.com. FAU - Boulenouar, Houssam AU - Boulenouar H AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria. Electronic address: boulenouar.houssam@gmail.com. FAU - Hamani-Medjaoui, Imane AU - Hamani-Medjaoui I AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria; Caisse Nationale des Assurances Sociales des travailleurs salaries, Clinique Specialisee en Orthopedie et Reeducation des Victimes des Accidents de Travail, Hai Bouamama (El Hassi) Oran, Algeria. Electronic address: amanim20002000@yahoo.fr. FAU - Saidi-Mehtar, Nadhira AU - Saidi-Mehtar N AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria. Electronic address: nmehtar2002@yahoo.fr. FAU - Amouyel, Philippe AU - Amouyel P AD - INSERM, U1167, Institut Pasteur de Lille, Universite de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille cedex, France. Electronic address: Philippe.Amouyel@pasteur-lille.fr. FAU - Houti, Leila AU - Houti L AD - Laboratoire de Genetique Moleculaire et Cellulaire, Universite des Sciences et de Technologie d'Oran Mohamed Boudiaf, BP 1505, El M'Naouer, 31000 Oran, Algeria; Faculte de Medecine, Universite Djillali Liabes de Sidi Bel Abbes, BP 89, 22000 Sidi-Bel-Abbes, Algeria; Laboratoire des Systemes d'Information en Sante, Universite d'Oran, BP 1524, El M'Naouer, 31000 Oran, Algeria. Electronic address: leilahouti@yahoo.fr. FAU - Goumidi, Louisa AU - Goumidi L AD - INSERM, U1167, Institut Pasteur de Lille, Universite de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille cedex, France. Electronic address: louisa.goumidi@pasteur-lille.fr. FAU - Meirhaeghe, Aline AU - Meirhaeghe A AD - INSERM, U1167, Institut Pasteur de Lille, Universite de Lille, 1 rue du Pr. Calmette, BP 245, F-59019 Lille cedex, France. Electronic address: Aline.Meirhaeghe@pasteur-lille.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150428 PL - Netherlands TA - Gene JT - Gene JID - 7706761 RN - 0 (Insulin) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Adult MH - Algeria MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/blood/*genetics MH - Female MH - Gene Frequency MH - Genetic Association Studies MH - Genetic Predisposition to Disease MH - Humans MH - Insulin/blood MH - Insulin Resistance/genetics MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*genetics MH - Phenotype MH - Polymorphism, Single Nucleotide MH - Risk OTO - NOTNLM OT - BNP OT - ISOR study OT - Insulin OT - NPPB gene OT - Polymorphism EDAT- 2015/05/03 06:00 MHDA- 2015/08/13 06:00 CRDT- 2015/05/03 06:00 PHST- 2015/03/13 00:00 [received] PHST- 2015/04/14 00:00 [revised] PHST- 2015/04/27 00:00 [accepted] PHST- 2015/05/03 06:00 [entrez] PHST- 2015/05/03 06:00 [pubmed] PHST- 2015/08/13 06:00 [medline] AID - S0378-1119(15)00515-6 [pii] AID - 10.1016/j.gene.2015.04.073 [doi] PST - ppublish SO - Gene. 2015 Aug 10;567(2):159-63. doi: 10.1016/j.gene.2015.04.073. Epub 2015 Apr 28.