PMID- 25934266
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20181113
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 46
IP  - 1
DP  - 2015 May 1
TI  - Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral 
      miRNA expression in an experimental infection.
PG  - 48
LID - 10.1186/s13567-015-0181-4 [doi]
LID - 48
AB  - Porcine circovirus type 2 (PCV2) is a ssDNA virus causing PCV2-systemic disease 
      (PCV2-SD), one of the most important diseases in swine. MicroRNAs (miRNAs) are a 
      new class of small non-coding RNAs that regulate gene expression 
      post-transcriptionally. Viral miRNAs have recently been described and the number 
      of viral miRNAs has been increasing in the past few years. In this study, small 
      RNA libraries were constructed from two tissues of subclinically PCV2 infected 
      pigs to explore if PCV2 can encode viral miRNAs. The deep sequencing data 
      revealed that PCV2 does not express miRNAs in an in vivo subclinical infection.
FAU - Nunez-Hernandez, Fernando
AU  - Nunez-Hernandez F
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra, Cerdanyola del Valles, Spain. 
      fernando.nunez@cresa.uab.cat.
FAU - Perez, Lester J
AU  - Perez LJ
AD  - Centro Nacional de Sanidad Agropecuaria (CENSA), La Habana, Cuba. 
      lesterjosue@gmail.com.
FAU - Vera, Gonzalo
AU  - Vera G
AD  - Departament de Genetica Animal, Centre de Recerca en AgriGenomica (CRAG), 
      CSIC-IRTA-UAB-UB, Universitat Autonoma de Barcelona, Barcelona, Bellaterra, 
      Spain. gonzalo.vera@cragenomica.es.
FAU - Cordoba, Sarai
AU  - Cordoba S
AD  - Departament de Genetica Animal, Centre de Recerca en AgriGenomica (CRAG), 
      CSIC-IRTA-UAB-UB, Universitat Autonoma de Barcelona, Barcelona, Bellaterra, 
      Spain. Sarai.Cordoba@cragenomica.es.
FAU - Segales, Joaquim
AU  - Segales J
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra, Cerdanyola del Valles, Spain. 
      Joaquim.Segales@cresa.uab.cat.
AD  - Departament de Sanitat i Anatomia Animals, Universitat Autonoma de Barcelona, 
      Barcelona, Bellaterra, Spain. Joaquim.Segales@cresa.uab.cat.
FAU - Sanchez, Armand
AU  - Sanchez A
AD  - Departament de Genetica Animal, Centre de Recerca en AgriGenomica (CRAG), 
      CSIC-IRTA-UAB-UB, Universitat Autonoma de Barcelona, Barcelona, Bellaterra, 
      Spain. armand.sanchez@cragenomica.es.
AD  - Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona 
      (UAB), Barcelona, Bellaterra, Spain. armand.sanchez@cragenomica.es.
FAU - Nunez, Jose I
AU  - Nunez JI
AD  - Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat 
      Autonoma de Barcelona, Bellaterra, Cerdanyola del Valles, Spain. 
      ignacio.nunez@cresa.uab.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150501
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Animals
MH  - Asymptomatic Infections
MH  - Circoviridae Infections/*veterinary/virology
MH  - Circovirus/*genetics/metabolism
MH  - *Genome, Viral
MH  - MicroRNAs/*genetics
MH  - Polymerase Chain Reaction/veterinary
MH  - RNA, Viral/*genetics
MH  - Swine
MH  - Swine Diseases/*virology
PMC - PMC4416260
EDAT- 2015/05/03 06:00
MHDA- 2016/02/05 06:00
PMCR- 2015/05/01
CRDT- 2015/05/03 06:00
PHST- 2014/12/19 00:00 [received]
PHST- 2015/04/07 00:00 [accepted]
PHST- 2015/05/03 06:00 [entrez]
PHST- 2015/05/03 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1186/s13567-015-0181-4 [pii]
AID - 181 [pii]
AID - 10.1186/s13567-015-0181-4 [doi]
PST - epublish
SO  - Vet Res. 2015 May 1;46(1):48. doi: 10.1186/s13567-015-0181-4.