PMID- 25934485
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20150527
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 290
DP  - 2015 Sep 1
TI  - Brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) in 
      genetically defined fear-induced aggression.
PG  - 45-50
LID - S0166-4328(15)00296-X [pii]
LID - 10.1016/j.bbr.2015.04.041 [doi]
AB  - The brain-derived neurotrophic factor (BDNF), its precursor (proBDNF) and BDNF 
      mRNA levels were studied in the brain of wild rats selectively bred for more than 
      70 generations for either high level or for the lack of affective aggressiveness 
      towards man. Significant increase of BDNF mRNA level in the frontal cortex and 
      increase of BDNF level in the hippocampus of aggressive rats was revealed. In the 
      midbrain and hippocampus of aggressive rats proBDNF level was increased, whereas 
      BDNF/proBDNF ratio was reduced suggesting the prevalence and increased influence 
      of proBDNF in highly aggressive rats. In the frontal cortex, proBDNF level in 
      aggressive rats was decreased. Thus, considerable structure-specific differences 
      in BDNF and proBDNF levels as well as in BDNF gene expression between highly 
      aggressive and nonaggressive rats were shown. The data suggested the implication 
      of BDNF and its precursor proBDNF in the mechanism of aggressiveness and in the 
      creation of either aggressive or nonaggressive phenotype.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ilchibaeva, Tatiana V
AU  - Ilchibaeva TV
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia.
FAU - Kondaurova, Elena M
AU  - Kondaurova EM
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
FAU - Tsybko, Anton S
AU  - Tsybko AS
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia.
FAU - Kozhemyakina, Rimma V
AU  - Kozhemyakina RV
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia.
FAU - Popova, Nina K
AU  - Popova NK
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
FAU - Naumenko, Vladimir S
AU  - Naumenko VS
AD  - Institute of Cytology and Genetics, Siberian Division of the Russian Academy of 
      Science, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia. 
      Electronic address: naumenko2002@bionet.nsc.ru.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150428
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aggression/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Fear
MH  - Frontal Lobe/*metabolism
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mesencephalon/*metabolism
MH  - Protein Precursors/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
OTO - NOTNLM
OT  - BDNF and proBDNF levels
OT  - BDNF expression
OT  - BDNF mRNA level
OT  - Genetically defined aggression
OT  - Rats
EDAT- 2015/05/03 06:00
MHDA- 2016/04/05 06:00
CRDT- 2015/05/03 06:00
PHST- 2015/03/20 00:00 [received]
PHST- 2015/04/21 00:00 [revised]
PHST- 2015/04/23 00:00 [accepted]
PHST- 2015/05/03 06:00 [entrez]
PHST- 2015/05/03 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
AID - S0166-4328(15)00296-X [pii]
AID - 10.1016/j.bbr.2015.04.041 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Sep 1;290:45-50. doi: 10.1016/j.bbr.2015.04.041. Epub 2015 
      Apr 28.