PMID- 25934492
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20150527
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 290
DP  - 2015 Sep 1
TI  - Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of 
      adult mice, in the absence of an immune challenge.
PG  - 51-60
LID - S0166-4328(15)00295-8 [pii]
LID - 10.1016/j.bbr.2015.04.040 [doi]
AB  - Tumor necrosis factor alpha (TNF-alpha) is a vital component of the immune system and 
      CNS. We previously showed that 3-month-old TNF-alpha and TNF-alpha receptor knockout mice 
      had impaired cognition, whilst at 12-months-old mice had better cognition. To 
      extend these findings on possible age-dependent TNF-alpha effects in the brain, we 
      investigated the behaviour of 6-month-old TNF-alpha knockout mice and their 
      neurobiological correlates. 6-month-old TNF(-/-), TNF-R1(-/-) and TNF-R2(-/-) 
      mice were compared to age-matched WT mice and tested for various behaviours. 
      ELISA hippocampal levels of nerve growth factor (NGF) and brain derived 
      neurotrophic factor (BDNF) and qPCR mRNA levels of Tnfa, Tnfr1, Tnfr2, Il10 and 
      Il1beta were measured. TNF-R1(-/-) and TNF(-/-) mice were found to have lesser 
      exploratory behaviour than WT mice, while TNF-R1(-/-) mice displayed better 
      memory than WT and TNF-R2(-/-) mice. Both TNF(-/-) and TNF-R2(-/-) mice exhibited 
      significantly lower immobility on the depression test than WT mice. Additionally, 
      TNF(-/-) mice expressed significantly lower levels of BDNF than WT mice in the 
      hippocampus while TNF-R1(-/-) mice displayed significantly lower BDNF levels 
      compared to both WT and TNF-R2(-/-) mice. TNF-R2(-/-) mice also displayed 
      significantly higher levels of NGF compared to TNF-R1(-/-) mice. These results 
      illustrate that TNF-alpha and its receptors mediate several behavioural phenotypes. 
      Finally, BDNF and NGF levels appear to be regulated by TNF-alpha and its receptors 
      even under immunologically unchallenged conditions.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Camara, Marie Lou
AU  - Camara ML
AD  - Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 
      SA, Australia; Discipline of Anatomy, School of Medicine, James Cook University, 
      Townsville QLD, Australia.
FAU - Corrigan, Frances
AU  - Corrigan F
AD  - Discipline of Anatomy and Pathology, School of Medical Sciences, University of 
      Adelaide, SA, Australia.
FAU - Jaehne, Emily J
AU  - Jaehne EJ
AD  - Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 
      SA, Australia.
FAU - Jawahar, M Catharine
AU  - Jawahar MC
AD  - Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 
      SA, Australia.
FAU - Anscomb, Helen
AU  - Anscomb H
AD  - Discipline of Anatomy, School of Medicine, James Cook University, Townsville QLD, 
      Australia.
FAU - Baune, Bernhard T
AU  - Baune BT
AD  - Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, 
      SA, Australia. Electronic address: Bernhard.Baune@Adelaide.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150428
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*metabolism
MH  - Exploratory Behavior/*physiology
MH  - Hippocampus/*metabolism
MH  - Humans
MH  - Male
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nerve Growth Factors/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I/*physiology
MH  - Receptors, Tumor Necrosis Factor, Type II/metabolism
MH  - Tumor Necrosis Factor-alpha/*physiology
OTO - NOTNLM
OT  - Cognition
OT  - Depression
OT  - Neurotrophins
OT  - TNF-alpha
OT  - TNF-alpha receptor
EDAT- 2015/05/03 06:00
MHDA- 2016/04/05 06:00
CRDT- 2015/05/03 06:00
PHST- 2015/01/27 00:00 [received]
PHST- 2015/04/21 00:00 [revised]
PHST- 2015/04/23 00:00 [accepted]
PHST- 2015/05/03 06:00 [entrez]
PHST- 2015/05/03 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
AID - S0166-4328(15)00295-8 [pii]
AID - 10.1016/j.bbr.2015.04.040 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Sep 1;290:51-60. doi: 10.1016/j.bbr.2015.04.040. Epub 2015 
      Apr 28.