PMID- 25935407
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20220311
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 297
DP  - 2015 Oct 30
TI  - Maternal exposure to di-(2-ethylhexyl) phthalate disrupts placental growth and 
      development in pregnant mice.
PG  - 25-33
LID - S0304-3894(15)00363-5 [pii]
LID - 10.1016/j.jhazmat.2015.04.065 [doi]
AB  - Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and widely dispersed 
      in the environment. DEHP exposure reduces embryo implantations, increases 
      embryonic loss, and decreases fetal body weights. However, no detailed 
      information is available about the effect of DEHP on the placentation during 
      pregnancy. Thus, our aim was to explore the effect of DEHP on the growth and 
      development of placenta in vivo. Mice were administered DEHP by gavages at 125, 
      250, 500 mg/kg/day from gestational days (GD) 1 until sacrifice. Results showed 
      that DEHP treatment significantly reduced the weight of placenta at GD 13. 
      Histopathologically, in DEHP-treated group, the ectoplacental cones significantly 
      became smaller at GD9, and total area of placenta and area of spongiotrophoblast 
      were significantly reduced at GD 13. Expression levels of Ascl2, Esx1 and Fosl1 
      mRNA dramatically decreased in DEHP-treated placenta at GD 13. DEHP 
      administration disrupted labyrinth vascularization of placentas, and inhibited 
      proliferation and induced apoptosis of placenta by the activation of caspase-3 
      and -8, up-regulation of Bax and down-regulation of Bcl-2 mRNA and protein at GD 
      13. In conclusion, these results suggest that adverse pregnancy outcomes 
      including low birth-weight and pregnancy loss exposed to DEHP are possibly 
      mediated, at least in part, via the suppression of placental growth and 
      development.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Zong, Teng
AU  - Zong T
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Lai, Lidan
AU  - Lai L
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Hu, Jia
AU  - Hu J
AD  - Department of Obstetrics and Gynecology, The First Affiliated Hospital of 
      Nanchang University, Nanchang, Jiangxi, China.
FAU - Guo, Meijun
AU  - Guo M
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Li, Mo
AU  - Li M
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Zhong, Chengxue
AU  - Zhong C
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Yang, Bei
AU  - Yang B
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Wu, Lei
AU  - Wu L
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Zhang, Dalei
AU  - Zhang D
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China.
FAU - Kuang, Haibin
AU  - Kuang H
AD  - Department of Physiology, School of Medicine, Nanchang University, Nanchang, 
      Jiangxi 330006, China. Electronic address: kuanghaibin@ncu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150424
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Environmental Pollutants)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Embryo Implantation/drug effects
MH  - Embryo Loss/chemically induced
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Gene Expression/drug effects
MH  - Maternal Exposure/*adverse effects
MH  - Mice, Inbred Strains
MH  - Organ Size/drug effects
MH  - Placenta/blood supply/*drug effects/pathology
MH  - Pregnancy
OTO - NOTNLM
OT  - DEHP
OT  - Mouse
OT  - Placenta
OT  - Pregnancy
OT  - Toxicity
EDAT- 2015/05/04 06:00
MHDA- 2016/05/25 06:00
CRDT- 2015/05/04 06:00
PHST- 2015/01/11 00:00 [received]
PHST- 2015/04/20 00:00 [revised]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/05/04 06:00 [entrez]
PHST- 2015/05/04 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
AID - S0304-3894(15)00363-5 [pii]
AID - 10.1016/j.jhazmat.2015.04.065 [doi]
PST - ppublish
SO  - J Hazard Mater. 2015 Oct 30;297:25-33. doi: 10.1016/j.jhazmat.2015.04.065. Epub 
      2015 Apr 24.