PMID- 25935693
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20150824
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1620
DP  - 2015 Sep 16
TI  - Long-and short-range functional connectivity density alteration in non-alcoholic 
      cirrhotic patients one month after liver transplantation: A resting-state fMRI 
      study.
PG  - 177-87
LID - S0006-8993(15)00342-X [pii]
LID - 10.1016/j.brainres.2015.04.046 [doi]
AB  - PURPOSE: To longitudinally evaluate long- and short-range functional connectivity 
      density (FCD) alteration in cirrhotic patients one month after liver 
      transplantation (LT) and their correlation with cognitive changes by using 
      resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: Twenty 
      seven candidates awaiting LT and 24 age-, gender-, and education-matched healthy 
      controls (HCs) were studied. All 27 patients and HCs performed rs-fMRI 
      examinations. Of 27 cirrhotic patients, 13 patients received LT underwent the 
      repeated rs-fMRI examinations one month after LT. Laboratory and psychometric 
      tests were carried out. The long- and short-range FCD maps derived from degree 
      centrality calculation were compared. Correlations between FCD alteration and 
      laboratory/psychometric changes were evaluated as well. RESULTS: In cirrhotic 
      patients, most of the brain areas with altered long- and short-range FCD could 
      reverse one month after LT, which was accompanied with cognitive and liver 
      functional improvement. The reduced long-range FCD in right posterior cingulate 
      cortex (PCC) and Left middle frontal gyrus (MFG), and reduced short-range FCD in 
      right precuneus (PCu) persisted in the early period after LT. In addition, one 
      month after LT, the post-LT group showed reduced long-range FCD in right rectus 
      gyrus (REC) and left medial prefrontal cortex (MPFC), and reduced short-range FCD 
      in left middle temporal gyrus (MTG), when compared with the pre-LT group. We 
      found Deltadigital symbol test (DeltaDST) score positively correlated with long-range 
      DeltaFCD in right precentral gyrus (preCG) (r = 0.72, P < 0.01) and right 
      supplementary motor area (SMA) (r = 0.59, P < 0.05). CONCLUSION: LT results in 
      favorable effect on cognitive function in cirrhotic patient, which can be 
      reflected by FCD alteration. However, persistence of PCC/PCu functional 
      connectivity disturbance one month after LT indicates complete cognitive function 
      restoration may need a longer time.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Zhang, Xiao-Dong
AU  - Zhang XD
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing Clinical School, 
      Southern Medical University, Nanjing 210002, Jiangsu Province, PR China; 
      Department of Radiology, Tianjin First Central Hospital, Clinical School of 
      Tianjin Medical University, Tianjin 300192, PR China; Department of Medical 
      Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, 
      Jiangsu Province, PR China.
FAU - Cheng, Yue
AU  - Cheng Y
AD  - Department of Radiology, Tianjin First Central Hospital, Clinical School of 
      Tianjin Medical University, Tianjin 300192, PR China.
FAU - Poon, Colin S
AU  - Poon CS
AD  - Department of Diagnostic Radiology, Yale University School of Medicine, New 
      Haven, CT, United States.
FAU - Qi, Rongfeng
AU  - Qi R
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China.
FAU - Xu, Qiang
AU  - Xu Q
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China.
FAU - Chen, Hui-Juan
AU  - Chen HJ
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China.
FAU - Kong, Xiang
AU  - Kong X
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China.
FAU - Lu, Guang-Ming
AU  - Lu GM
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China.
FAU - Shen, Wen
AU  - Shen W
AD  - Department of Radiology, Tianjin First Central Hospital, Clinical School of 
      Tianjin Medical University, Tianjin 300192, PR China.
FAU - Zhang, Long-Jiang
AU  - Zhang LJ
AD  - Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing 
      University, Nanjing 210002, Jiangsu Province, PR China. Electronic address: 
      kevinzhlj@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150430
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis, Alcoholic/*physiopathology/*surgery
MH  - *Liver Transplantation
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Neuronal Plasticity
MH  - Prospective Studies
MH  - Rest
MH  - Signal Processing, Computer-Assisted
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cirrhosis
OT  - Functional connectivity
OT  - Functional magnetic resonance imaging
OT  - Liver transplantation
OT  - Resting-state
EDAT- 2015/05/04 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/05/04 06:00
PHST- 2015/01/23 00:00 [received]
PHST- 2015/04/14 00:00 [revised]
PHST- 2015/04/17 00:00 [accepted]
PHST- 2015/05/04 06:00 [entrez]
PHST- 2015/05/04 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - S0006-8993(15)00342-X [pii]
AID - 10.1016/j.brainres.2015.04.046 [doi]
PST - ppublish
SO  - Brain Res. 2015 Sep 16;1620:177-87. doi: 10.1016/j.brainres.2015.04.046. Epub 
      2015 Apr 30.