PMID- 25936592
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20220317
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 597
DP  - 2015 Jun 15
TI  - Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and 
      brain-derived neurotrophic factor following audiogenic seizures.
PG  - 154-8
LID - S0304-3940(15)00345-6 [pii]
LID - 10.1016/j.neulet.2015.04.046 [doi]
AB  - Increasing body of evidence suggests that inflammatory and neurotrophic factors 
      might be important for epileptogenesis. Most animal studies demonstrated altered 
      levels of these mediators in drug-induced models of seizures and epilepsy. In the 
      present study, we investigated the production of cytokines and a neurotrophin in 
      the brain of Wistar Audiogenic Rats (WAR), a genetic model of epilepsy, 
      stimulated with high-intensity sound. Four hours after stimulation, animals were 
      decapitated and the hippocampus, inferior colliculus, striatum and cortex were 
      removed for evaluation of the levels of interleukin (IL)-1beta, IL-6, tumor necrosis 
      factor (TNF)-alpha and brain derived neurotrophic factor (BDNF). All the cytokines 
      and BDNF levels were increased in the cortex. Increased levels of TNF-alpha and IL-6 
      were also observed in the striatum. Finally, TNF-alpha also increased in the inferior 
      colliculus after the seizures induced by high-intensity sound. Although different 
      studies have demonstrated that the levels of cytokines and BDNF increase in 
      animal models of epilepsy induced by chemical stimuli, we provided here evidence 
      that these mediators are also increased in WAR, a genetic model of epilepsy. 
      Thus, the observed increase in these mediators might be involved in the 
      pathophysiology of epilepsy.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - de Souza Bernardino, Tulio Cezar
AU  - de Souza Bernardino TC
AD  - Department of Pharmacology, Brazil.
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
AD  - Department of Internal Medicine, Brazil.
FAU - Miranda, Aline Silva
AU  - Miranda AS
AD  - Department of Internal Medicine, Brazil.
FAU - Guidine, Patricia Maia
AU  - Guidine PM
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Rezende, Gustavo
AU  - Rezende G
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Doretto, Maria Carolina
AU  - Doretto MC
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Castro, Gabriel Perfeito
AU  - Castro GP
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Drummond, Luciana
AU  - Drummond L
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Moraes, Marcio Flavio Dutra
AU  - Moraes MF
AD  - Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Tito, Pedro Augusto Lopes
AU  - Tito PA
AD  - Department of Pharmacology, Brazil.
FAU - de Oliveira, Antonio Carlos Pinheiro
AU  - de Oliveira AC
AD  - Department of Pharmacology, Brazil.
FAU - Reis, Helton Jose
AU  - Reis HJ
AD  - Department of Pharmacology, Brazil. Electronic address: heltonjr@icb.ufmg.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150430
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cytokines/*metabolism
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Rats, Wistar
MH  - Seizures/etiology/*metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Cytokines
OT  - Inflammation
OT  - Seizures
OT  - Wistar Audiogenic Rats
EDAT- 2015/05/06 06:00
MHDA- 2015/10/20 06:00
CRDT- 2015/05/05 06:00
PHST- 2015/03/06 00:00 [received]
PHST- 2015/04/13 00:00 [revised]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/05/05 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - S0304-3940(15)00345-6 [pii]
AID - 10.1016/j.neulet.2015.04.046 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Jun 15;597:154-8. doi: 10.1016/j.neulet.2015.04.046. Epub 
      2015 Apr 30.