PMID- 25937189
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20191220
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Print)
IS  - 1476-0584 (Linking)
VI  - 14
IP  - 7
DP  - 2015 Jul
TI  - Adversomics: a new paradigm for vaccine safety and design.
PG  - 935-47
LID - 10.1586/14760584.2015.1038249 [doi]
AB  - Despite the enormous population benefits of routine vaccination, vaccine adverse 
      events (AEs) and reactions, whether real or perceived, have posed one of the 
      greatest barriers to vaccine acceptance--and thus to infectious disease 
      prevention--worldwide. A truly integrated clinical, translational, and basic 
      science approach is required to understand the mechanisms behind vaccine AEs, 
      predict them, and then apply this knowledge to new vaccine design approaches that 
      decrease, or avoid, these events. The term 'adversomics' was first introduced in 
      2009 and refers to the study of vaccine adverse reactions using immunogenomics 
      and systems biology approaches. In this review, we present the current state of 
      adversomics research, review known associations and mechanisms of vaccine 
      AEs/reactions, and outline a plan for the further development of this emerging 
      research field.
FAU - Whitaker, Jennifer A
AU  - Whitaker JA
AD  - Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - U01 AI089859/AI/NIAID NIH HHS/United States
GR  - U01AI089859/AI/NIAID NIH HHS/United States
GR  - R01 AI033144/AI/NIAID NIH HHS/United States
GR  - N01 AI040065/AI/NIAID NIH HHS/United States
GR  - N01AI40065/AI/NIAID NIH HHS/United States
GR  - R01AI033144/AI/NIAID NIH HHS/United States
GR  - R37 AI048793/AI/NIAID NIH HHS/United States
GR  - R37AI048793/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150502
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Vaccines)
SB  - IM
MH  - Biomedical Research/trends
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology/*prevention & 
      control
MH  - Humans
MH  - Immunogenetics/methods
MH  - *Patient Acceptance of Health Care
MH  - Systems Biology/methods
MH  - Vaccines/*administration & dosage/*adverse effects
PMC - PMC4630804
MID - NIHMS732579
OTO - NOTNLM
OT  - drug-related side effects and adverse reactions
OT  - genetic association studies
OT  - genomics
OT  - immunogenetics
OT  - individualized medicine
OT  - polymorphism
OT  - single nucleotide
OT  - systems biology
OT  - vaccination
OT  - vaccines
OT  - viral vaccines
COIS- Financial and competing interests disclosure This research has been reviewed by 
      the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance 
      with Mayo Clinic Conflict of Interest policies. The authors have no other 
      relevant affiliations or financial involvement with any organization or entity 
      with a financial interest in or financial conflict with the subject matter or 
      materials discussed in the manuscript apart from those disclosed.
EDAT- 2015/05/06 06:00
MHDA- 2016/03/02 06:00
PMCR- 2016/07/01
CRDT- 2015/05/05 06:00
PHST- 2015/05/05 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - 10.1586/14760584.2015.1038249 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2015 Jul;14(7):935-47. doi: 10.1586/14760584.2015.1038249. 
      Epub 2015 May 2.