PMID- 25938018
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150504
LR  - 20200930
IS  - 2210-9099 (Print)
IS  - 2233-6052 (Electronic)
IS  - 2210-9099 (Linking)
VI  - 6
IP  - 2
DP  - 2015 Apr
TI  - Association of TNF-alpha 308 G/A Polymorphism With Type 2 Diabetes: A Case-Control 
      Study in the Iranian Kurdish Ethnic Group.
PG  - 94-9
LID - 10.1016/j.phrp.2015.01.003 [doi]
AB  - OBJECTIVES: Tumor necrosis factor-alpha (TNF-alpha) plays roles in the development of 
      obesity, insulin resistance, and possibility of Type 2 diabetes mellitus (T2DM). 
      The objective of the current study was to evaluate the association of TNF-alpha 
      promoter-308 G/A polymorphism with T2DM. METHODS: In all, 1038 patients with T2DM 
      and 1023 normoglycemic controls were included in this study. All participants 
      were genotyped using the polymerase chain reaction-restriction fragment length 
      polymorphism method. Genotypic and allelic frequencies were then analyzed in each 
      group. Serum lipids, fasting glucose, fasting serum insulin, homeostatic model 
      assessment of insulin resistance, and hemoglogin A1c levels were determined by 
      conventional methods. RESULTS: The allelic frequency of the A allele was 
      significantly different between case and control participants (p = 0.006). 
      Genotypes GA and AA were found to be significantly associated with 2.24- and 
      3.18-fold increased risk for T2DM, respectively. Similarly, the dominant model of 
      -308 G/A polymorphism was found to have a higher risk for T2DM (odds 
      ratio = 2.34, p = 0.001). Individuals with T2DM carrying the GA + AA genotypes of 
      -308 G/A variation had significantly lower fasting plasma insulin than those 
      carrying GG genotype. CONCLUSION: Our findings revealed that there is an 
      association between the TNF-alpha promoter -308 G/A polymorphism and T2DM in this 
      population.
FAU - Golshani, Hasan
AU  - Golshani H
AD  - Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
FAU - Haghani, Karimeh
AU  - Haghani K
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of 
      Medical Sciences, Ilam, Iran.
FAU - Dousti, Majid
AU  - Dousti M
AD  - Department of Parasitology, Faculty of Medicine, Ilam University of Medical 
      Sciences, Ilam, Iran.
FAU - Bakhtiyari, Salar
AU  - Bakhtiyari S
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of 
      Medical Sciences, Ilam, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150219
PL  - Korea (South)
TA  - Osong Public Health Res Perspect
JT  - Osong public health and research perspectives
JID - 101563309
PMC - PMC4411339
OTO - NOTNLM
OT  - -308 TNF-alpha promoter
OT  - Kurd
OT  - case-control
OT  - polymorphism
OT  - type 2 diabetes
EDAT- 2015/05/06 06:00
MHDA- 2015/05/06 06:01
PMCR- 2015/02/19
CRDT- 2015/05/05 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2014/11/20 00:00 [revised]
PHST- 2015/01/15 00:00 [accepted]
PHST- 2015/05/05 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2015/05/06 06:01 [medline]
PHST- 2015/02/19 00:00 [pmc-release]
AID - S2210-9099(15)00006-5 [pii]
AID - 10.1016/j.phrp.2015.01.003 [doi]
PST - ppublish
SO  - Osong Public Health Res Perspect. 2015 Apr;6(2):94-9. doi: 
      10.1016/j.phrp.2015.01.003. Epub 2015 Feb 19.