PMID- 25938439
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 5
DP  - 2015
TI  - Novel Clinical Evidence of an Association between Homocysteine and Insulin 
      Resistance in Patients with Hypothyroidism or Subclinical Hypothyroidism.
PG  - e0125922
LID - 10.1371/journal.pone.0125922 [doi]
LID - e0125922
AB  - OBJECTIVE: Hypothyroidism (HO) can induce significant metabolic dysfunction and 
      increase cardiovascular disease risk. In the present study, we investigated the 
      relationship between homocysteine (Hcy) and insulin resistance (IR) in patients 
      with HO or subclinical hypothyroidism (SHO). METHODS: A total of 270 subjects 
      were enrolled. All subjects were divided into the following three groups: HO, SHO 
      and control. Plasma levels of Hcy were measured, and each patient's homeostatic 
      index of insulin resistance (HOMA-IR) was calculated. Statistical analyses were 
      carried out to evaluate the correlations among groups and to determine the 
      predictors of IR in patients with HO or SHO. RESULTS: The HOMA-IR value was 
      significantly higher in the HO group than in the SHO and control groups. Plasma 
      levels of Hcy were markedly increased in the HO group compared with those of the 
      SHO group and controls. In addition, plasma levels of Hcy were positively 
      correlated with the HOMA-IR values in both the HO and SHO groups. Multiple linear 
      regression models showed that plasma levels of Hcy and free thyroxine (FT4) were 
      the only predictors of HOMA-IR in patients with HO or SHO. CONCLUSIONS: Plasma 
      levels of Hcy and HOMA-IR were increased in patients with HO or SHO. Our results 
      suggest that HO and SHO may increase the risk for atherogenesis and 
      cardiovascular disease by increased IR. The increased IR induced by 
      hyperhomocysteinemia in patients with HO or SHO may partially explain this 
      adverse effect.
FAU - Yang, Ning
AU  - Yang N
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Yao, Zhi
AU  - Yao Z
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Miao, Li
AU  - Miao L
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Gao, Xia
AU  - Gao X
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Fan, Hui
AU  - Fan H
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Hu, Yanjin
AU  - Hu Y
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Qu, Aijuan
AU  - Qu A
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Science, 
      Capital Medical University, Beijing, People's Republic of China.
FAU - Wang, Guang
AU  - Wang G
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
LA  - eng
SI  - Dryad/10.5061/dryad.6H1S2
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150504
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Fasting
MH  - Female
MH  - Glycated Hemoglobin
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hypothyroidism/blood/diagnosis/*metabolism
MH  - *Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Thyroid Function Tests
PMC - PMC4418925
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/05/06 06:00
MHDA- 2016/02/03 06:00
PMCR- 2015/05/04
CRDT- 2015/05/05 06:00
PHST- 2015/01/06 00:00 [received]
PHST- 2015/03/26 00:00 [accepted]
PHST- 2015/05/05 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PHST- 2015/05/04 00:00 [pmc-release]
AID - PONE-D-14-58587 [pii]
AID - 10.1371/journal.pone.0125922 [doi]
PST - epublish
SO  - PLoS One. 2015 May 4;10(5):e0125922. doi: 10.1371/journal.pone.0125922. 
      eCollection 2015.