PMID- 25940002
OWN - NLM
STAT- MEDLINE
DCOM- 20180129
LR  - 20180619
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 21
IP  - 4
DP  - 2016 Jul
TI  - Paternal alcohol exposure in mice alters brain NGF and BDNF and increases 
      ethanol-elicited preference in male offspring.
PG  - 776-87
LID - 10.1111/adb.12255 [doi]
AB  - Ethanol (EtOH) exposure during pregnancy induces cognitive and physiological 
      deficits in the offspring. However, the role of paternal alcohol exposure (PAE) 
      on offspring EtOH sensitivity and neurotrophins has not received much attention. 
      The present study examined whether PAE may disrupt nerve growth factor (NGF) 
      and/or brain-derived neurotrophic factor (BDNF) and affect EtOH 
      preference/rewarding properties in the male offspring. CD1 sire mice were 
      chronically addicted for EtOH or administered with sucrose. Their male offsprings 
      when adult were assessed for EtOH preference by a conditioned place preference 
      paradigm. NGF and BDNF, their receptors (p75(NTR) , TrkA and TrkB), dopamine 
      active transporter (DAT), dopamine receptors D1 and D2, pro-NGF and pro-BDNF were 
      also evaluated in brain areas. PAE affected NGF levels in frontal cortex, 
      striatum, olfactory lobes, hippocampus and hypothalamus. BDNF alterations in 
      frontal cortex, striatum and olfactory lobes were found. PAE induced a higher 
      susceptibility to the EtOH rewarding effects mostly evident at the lower 
      concentration (0.5 g/kg) that was ineffective in non-PAE offsprings. Moreover, 
      higher ethanol concentrations (1.5 g/kg) produced an aversive response in PAE 
      animals and a significant preference in non-PAE offspring. PAE affected also TrkA 
      in the hippocampus and p75(NTR) in the frontal cortex. DAT was affected in the 
      olfactory lobes in PAE animals treated with 0.5 g/kg of ethanol while no 
      differences were found on D1/D2 receptors and for pro-NGF or pro-BDNF. In 
      conclusion, this study shows that: PAE affects NGF and BDNF expression in the 
      mouse brain; PAE may induce ethanol intake preference in the male offspring.
CI  - (c) 2015 Society for the Study of Addiction.
FAU - Ceccanti, Mauro
AU  - Ceccanti M
AD  - Centro Riferimento Alcologico Regione Lazio, Sapienza University of Rome, Italy.
FAU - Coccurello, Roberto
AU  - Coccurello R
AD  - Institute of Cell Biology and Neurobiology (IBCN)/IRCCS S. Lucia Foundation, 
      Italy.
FAU - Carito, Valentina
AU  - Carito V
AD  - Institute of Cell Biology and Neurobiology (IBCN)/IRCCS S. Lucia Foundation, 
      Italy.
FAU - Ciafre, Stefania
AU  - Ciafre S
AD  - Institute of Translational Pharmacology (IFT), National Research Council of Italy 
      (C.N.R.), Italy.
FAU - Ferraguti, Giampiero
AU  - Ferraguti G
AD  - Department of Cellular Biotechnologies and Hematology, Sapienza University of 
      Rome, Italy.
FAU - Giacovazzo, Giacomo
AU  - Giacovazzo G
AD  - Institute of Cell Biology and Neurobiology (IBCN)/IRCCS S. Lucia Foundation, 
      Italy.
FAU - Mancinelli, Rosanna
AU  - Mancinelli R
AD  - Centro Nazionale Sostanze Chimiche, Instituto Superiore di Sanita, Rome, Italy.
FAU - Tirassa, Paola
AU  - Tirassa P
AD  - Institute of Cell Biology and Neurobiology (IBCN)/IRCCS S. Lucia Foundation, 
      Italy.
FAU - Chaldakov, George N
AU  - Chaldakov GN
AD  - Laboratory of Cell Biology, Medical University, Bulgaria.
FAU - Pascale, Esterina
AU  - Pascale E
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Italy.
FAU - Ceccanti, Marco
AU  - Ceccanti M
AD  - Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
FAU - Codazzo, Claudia
AU  - Codazzo C
AD  - Centro Riferimento Alcologico Regione Lazio, Sapienza University of Rome, Italy.
FAU - Fiore, Marco
AU  - Fiore M
AD  - Institute of Cell Biology and Neurobiology (IBCN)/IRCCS S. Lucia Foundation, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150504
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
RN  - 57-50-1 (Sucrose)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Alcoholism/physiopathology
MH  - Animals
MH  - Blotting, Western
MH  - Brain/drug effects
MH  - Brain-Derived Neurotrophic Factor/*drug effects
MH  - Central Nervous System Depressants/*pharmacology
MH  - Chromatography, Gas
MH  - Disease Models, Animal
MH  - Ethanol/*pharmacology
MH  - *Fathers
MH  - Male
MH  - Mice
MH  - Nerve Growth Factor/*drug effects
MH  - Reward
MH  - Sucrose/administration & dosage
OTO - NOTNLM
OT  - Ethanol intake preference
OT  - neurotrophin
OT  - paternal alcohol exposure
EDAT- 2015/05/06 06:00
MHDA- 2018/01/30 06:00
CRDT- 2015/05/06 06:00
PHST- 2015/05/06 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2018/01/30 06:00 [medline]
AID - 10.1111/adb.12255 [doi]
PST - ppublish
SO  - Addict Biol. 2016 Jul;21(4):776-87. doi: 10.1111/adb.12255. Epub 2015 May 4.