PMID- 25941648
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150505
LR  - 20200930
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 19
IP  - Suppl 1
DP  - 2015 Apr
TI  - Understanding type 1 diabetes through genetics: Advances and prospects.
PG  - S39-43
LID - 10.4103/2230-8210.155391 [doi]
AB  - The largest contribution of type 1 diabetes mellitus (T1DM) from a single locus 
      comes from several genes located in the major histocompatibility complex on 
      chromosome 6p21. Because DQB1 is the best single genetic marker for T1DM, it is 
      the gene most often used to identify individuals with a high risk of developing 
      disease. As per the data collected from the All India Institute of Medical 
      Sciences, among the human leukocyte antigen (HLA)-DRB1 genes, HLA-DR3 showed 
      strongest association with the disease; however, unlike Caucasians and other 
      populations, DR4 was not significantly increased in these patients. HLA-DR10, 11, 
      13, and 15 showed a negative association with the disease as they were reduced in 
      these patients. In India, the relative risk of developing T1DM is higher with the 
      DR3-DQ2 haplotypes as compared to DR4-DQ8 haplotypes. Studies have shown that in 
      North India, the relative risk for T1DM is comparatively higher (>30) with the 
      DQ2/DQ8 genotype, but is relatively lower (approximately 18) for the DQ2/DQ2 
      genotype. In addition, the three sets of HLA-B-DR3 haplotypes, mainly B58-DR3, 
      B50-DR3, and B8-DR3 have shown to have modulated susceptibility for T1DM in India 
      and worldwide. New interventions that will be tested in the future will be 
      conducted through T1DM TrialNet, a collaborative network of clinical centers and 
      experts in diabetes and immunology. These studies will identify unaffected 
      first-degree relatives with beta cell autoantibodies who will be eligible for new 
      interventions.
FAU - Tandon, Nikhil
AU  - Tandon N
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC4413387
OTO - NOTNLM
OT  - Genes
OT  - genetics
OT  - type 1 diabetes mellitus
COIS- Conflict of Interest: None declared.
EDAT- 2015/05/06 06:00
MHDA- 2015/05/06 06:01
PMCR- 2015/04/01
CRDT- 2015/05/06 06:00
PHST- 2015/05/06 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2015/05/06 06:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - IJEM-19-39 [pii]
AID - 10.4103/2230-8210.155391 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2015 Apr;19(Suppl 1):S39-43. doi: 
      10.4103/2230-8210.155391.