PMID- 25941895
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150507
LR  - 20220330
IS  - 1044-7946 (Print)
IS  - 1044-7946 (Linking)
VI  - 20
IP  - 12
DP  - 2008 Dec
TI  - A Review of Collagen and Collagen-based Wound Dressings.
PG  - 347-56
AB  - Collagen is a key component of a healing wound. In this review, a general 
      description of the wound healing process is provided focusing on collagen's 
      unique role. The mode of action (MoA) of collagen-based dressings is also 
      addressed. Due to a number of potential stimuli (local tissue ischemia, 
      bioburden, necrotic tissue, repeated trauma, etc.), wounds can stall in the 
      inflammatory phase contributing to the chronicity of the wound. One key component 
      of chronic wounds is an elevated level of matrix metalloproteinases (MMPs). At 
      elevated levels, MMPs not only degrade nonviable collagen but also viable 
      collagen. In addition, fibroblasts in a chronic wound may not secrete tissue 
      inhibitors of MMPs (TIMPs) at an adequate level to control the activity of MMPs. 
      These events prevent the formation of the scaffold needed for cell migration and 
      ultimately prevent the formation of the extracellular matrix (ECM) and 
      granulation tissue. Collagen based wound dressings are uniquely suited to address 
      the issue of elevated levels of MMPs by acting as a 'sacrificial substrate' in 
      the wound. It has also been demonstrated that collagen breakdown products are 
      chemotactic for a variety of cell types required for the formation of granulation 
      tissue. In addition, collagen based dressings have the ability to absorb wound 
      exudates and maintain a moist wound environment.
FAU - Brett, David
AU  - Brett D
AD  - Wound Management Division, Smith & Nephew, St. Petersburg, Florida; Email: 
      dave.brett@smith-nephew.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Wounds
JT  - Wounds : a compendium of clinical research and practice
JID - 9010276
EDAT- 2008/12/01 00:00
MHDA- 2008/12/01 00:01
CRDT- 2015/05/06 06:00
PHST- 2015/05/06 06:00 [entrez]
PHST- 2008/12/01 00:00 [pubmed]
PHST- 2008/12/01 00:01 [medline]
PST - ppublish
SO  - Wounds. 2008 Dec;20(12):347-56.