PMID- 25942563
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20200306
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 5
DP  - 2015
TI  - NMDA Receptor Antagonist Attenuates Bleomycin-Induced Acute Lung Injury.
PG  - e0125873
LID - 10.1371/journal.pone.0125873 [doi]
LID - e0125873
AB  - BACKGROUND: Glutamate is a major neurotransmitter in the central nervous system 
      (CNS). Large amount of glutamate can overstimulate N-methyl-D-aspartate receptor 
      (NMDAR), causing neuronal injury and death. Recently, NMDAR has been reported to 
      be found in the lungs. The aim of this study is to examine the effects of 
      memantine, a NMDAR channel blocker, on bleomycin-induced lung injury mice. 
      METHODS: C57BL/6 mice were intratracheally injected with bleomycin (BLM) to 
      induce lung injury. Mice were randomized to receive saline, memantine (Me), BLM, 
      BLM plus Me. Lungs and BALF were harvested on day 3 or 7 for further evaluation. 
      RESULTS: BLM caused leukocyte infiltration, pulmonary edema and increase in 
      cytokines, and imposed significant oxidative stress (MDA as a marker) in lungs. 
      Memantine significantly mitigated the oxidative stress, lung inflammatory 
      response and acute lung injury caused by BLM. Moreover, activation of NMDAR 
      enhances CD11b expression on neutrophils. CONCLUSIONS: Memantine mitigates 
      oxidative stress, lung inflammatory response and acute lung injury in BLM 
      challenged mice.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Peng, XiangPing
AU  - Peng X
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China; Xiangya Nursing School, Central South University, 
      Changsha, Hunan, China.
FAU - Zhao, FeiYan
AU  - Zhao F
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Feng, DanDan
AU  - Feng D
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Han, JianZhong
AU  - Han J
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Huang, YanHong
AU  - Huang Y
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Luo, SiWei
AU  - Luo S
AD  - Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
FAU - Li, Lian
AU  - Li L
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Yue, Shao Jie
AU  - Yue SJ
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Cheng, QingMei
AU  - Cheng Q
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Huang, XiaoTing
AU  - Huang X
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
FAU - Luo, ZiQiang
AU  - Luo Z
AD  - Department of Physiology, Xiangya School of Medicine, Central South University, 
      Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150505
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Amino Acids)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (CD11b Antigen)
RN  - 0 (Cytokines)
RN  - 0 (Dopamine Agents)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 11056-06-7 (Bleomycin)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - W8O17SJF3T (Memantine)
SB  - IM
MH  - Acute Lung Injury/*chemically induced/drug therapy/*metabolism/pathology
MH  - Amino Acids/metabolism
MH  - Animals
MH  - Antibiotics, Antineoplastic/*adverse effects
MH  - Bleomycin/*adverse effects
MH  - Bronchoalveolar Lavage Fluid
MH  - CD11b Antigen/metabolism
MH  - Capillary Permeability
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Dopamine Agents/pharmacology
MH  - Female
MH  - Glutamic Acid/metabolism
MH  - Malondialdehyde/metabolism
MH  - Memantine/pharmacology
MH  - Mice
MH  - Neutrophil Infiltration
MH  - Neutrophils/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
PMC - PMC4420245
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/05/06 06:00
MHDA- 2016/02/03 06:00
PMCR- 2015/05/05
CRDT- 2015/05/06 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/03/26 00:00 [accepted]
PHST- 2015/05/06 06:00 [entrez]
PHST- 2015/05/06 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PHST- 2015/05/05 00:00 [pmc-release]
AID - PONE-D-14-56600 [pii]
AID - 10.1371/journal.pone.0125873 [doi]
PST - epublish
SO  - PLoS One. 2015 May 5;10(5):e0125873. doi: 10.1371/journal.pone.0125873. 
      eCollection 2015.