PMID- 25943323
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20181202
IS  - 2005-9256 (Electronic)
IS  - 1598-2998 (Print)
IS  - 1598-2998 (Linking)
VI  - 48
IP  - 1
DP  - 2016 Jan
TI  - Novel Methods of Lymph Node Evaluation for Predicting the Prognosis of Colorectal 
      Cancer Patients with Inadequate Lymph Node Harvest.
PG  - 216-24
LID - 10.4143/crt.2014.312 [doi]
AB  - PURPOSE: Lymph node metastasis is an important factor for predicting the 
      prognosis of colorectal cancer patients. However, approximately 60% of patients 
      do not receive adequate lymph node evaluation (less than 12 lymph nodes). In this 
      study, we identified a more effective tool for predicting the prognosis of 
      patients who received inadequate lymph node evaluation. MATERIALS AND METHODS: 
      The number of metastatic lymph nodes, total number of lymph nodes examined, 
      number of negative metastatic lymph nodes (NL), lymph node ratio (LR), and the 
      number of apical lymph nodes (APL) were examined, and the prognostic impact of 
      these parameters was examined in patients with colorectal cancer who underwent 
      surgery from January 2004 to December 2011. In total, 806 people were analyzed 
      retrospectively. RESULTS: In comparison of different lymph node analysis methods 
      for rectal cancer patients who did not receive adequate lymph node dissection, 
      the LR showed a significant difference in overall survival (OS) and the APL 
      predicted a significant difference in disease-free survival (DFS). In the case of 
      colon cancer patients who did not receive adequate lymph node dissection, LR 
      predicted a significant difference in DFS and OS, and the APL predicted a 
      significant difference in DFS. CONCLUSION: If patients did not receive adequate 
      lymph node evaluation, the LR and NL were useful parameters to complement N stage 
      for predicting OS in colon cancer, whereas LR was complementary for rectal 
      cancer. The APL could be used for prediction of DFS in all patients.
FAU - Kwon, Taek Soo
AU  - Kwon TS
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Choi, Sung Bong
AU  - Choi SB
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Lee, Yoon Suk
AU  - Lee YS
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Kim, Jun-Gi
AU  - Kim JG
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Oh, Seong Taek
AU  - Oh ST
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Lee, In Kyu
AU  - Lee IK
AD  - Department of Surgery, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150415
PL  - Korea (South)
TA  - Cancer Res Treat
JT  - Cancer research and treatment
JID - 101155137
SB  - IM
MH  - Colorectal Neoplasms/*diagnosis/pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*pathology/*surgery
MH  - Lymphatic Metastasis/*diagnosis/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Rectal Neoplasms/diagnosis/pathology
MH  - Retrospective Studies
PMC - PMC4720064
OTO - NOTNLM
OT  - Colorectal neoplasms
OT  - Lymph node ratio
OT  - Lymph nodes
OT  - Negative lymph nodes
OT  - Prognosis
COIS- Conflict of interest relevant to this article was not reported.
EDAT- 2015/05/07 06:00
MHDA- 2018/06/12 06:00
PMCR- 2016/01/01
CRDT- 2015/05/07 06:00
PHST- 2014/10/31 00:00 [received]
PHST- 2015/03/07 00:00 [accepted]
PHST- 2015/05/07 06:00 [entrez]
PHST- 2015/05/07 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - crt.2014.312 [pii]
AID - crt-2014-312 [pii]
AID - 10.4143/crt.2014.312 [doi]
PST - ppublish
SO  - Cancer Res Treat. 2016 Jan;48(1):216-24. doi: 10.4143/crt.2014.312. Epub 2015 Apr 
      15.