PMID- 25943639
OWN - NLM
STAT- MEDLINE
DCOM- 20160115
LR  - 20150506
IS  - 2210-7797 (Electronic)
IS  - 2210-7789 (Linking)
VI  - 5
IP  - 2
DP  - 2015 Apr
TI  - Pregnancy outcomes in women with heart disease: Experience of a tertiary center 
      in the Netherlands.
PG  - 165-70
LID - S2210-7789(14)00439-5 [pii]
LID - 10.1016/j.preghy.2014.12.001 [doi]
AB  - OBJECTIVES: Clinical data of pregnant women with heart disease were obtained with 
      the intention to provide input for local counseling and management guidelines. 
      STUDY DESIGN: Retrospective data from all pregnant women with congenital or 
      acquired heart disease between 2000 and 2011 in the VU University Medical Centre 
      Amsterdam. MAIN OUTCOME MEASURES: Maternal and neonatal outcomes were evaluated. 
      RESULTS: Data of 122 women with 160 pregnancies were obtained. The most common 
      heart diseases were congenital heart disease (n=65, 53.3%) and arrhythmia (n = 
      20, 16.4%). Based on the functional criteria of the New York Heart Association 
      (NYHA), 114/122 patients (93.4%) were classified NYHA class I-II. Patients in 
      NYHA class III-IV (n = 8/122, 6.6%), mainly had a history of myocardial 
      infarction or pulmonary hypertension. There were 156 singleton and 4 twin 
      pregnancies. 22 (13.5%) pregnancies were complicated by hypertensive disorders. 
      Heart failure developed in 11 women (9.0%), 37.5% in NYHA class III-IV and 6.5% 
      in NYHA class I-II. Mean gestational age and birth weight were 270 days and 3196 
      g in NYHA class I-II compared to 237 days and 1972 g for NHYA class III-IV. There 
      were two maternal deaths (1.6%) and 5 fetal deaths (3.1%). There were 29 (12.8%) 
      preterm births, 20 (12.8%) neonates small for gestational age and 34 (21.8%) 
      admittances on the Neonatal Intensive Care Unit (NICU). CONCLUSIONS: Pregnancy in 
      women with pre-existing heart disease in all NYHA classes is associated with 
      increased maternal morbidity and perinatal morbidity. Risk of structural fetal 
      anomalies is especially high in women with congenital heart disease.
CI  - Copyright (c) 2015 International Society for the Study of Hypertension in 
      Pregnancy. Published by Elsevier B.V. All rights reserved.
FAU - Hink, E
AU  - Hink E
AD  - VU University Medical Centre, Boelelaan 1117, Department of Gynecology and 
      Obstetrics, 1081 HZ Amsterdam, The Netherlands. Electronic address: 
      e.hink@vumc.nl.
FAU - Bolte, A C
AU  - Bolte AC
AD  - VU University Medical Centre, Boelelaan 1117, Department of Gynecology and 
      Obstetrics, 1081 HZ Amsterdam, The Netherlands. Electronic address: 
      Annemieke.Bolte@radboudumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20150105
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
SB  - IM
MH  - Abortion, Induced/statistics & numerical data
MH  - Adult
MH  - Birth Weight
MH  - Delivery, Obstetric/statistics & numerical data
MH  - Female
MH  - Heart Diseases/*epidemiology
MH  - Humans
MH  - Netherlands/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*epidemiology
MH  - Pregnancy Outcome/epidemiology
MH  - Premature Birth/epidemiology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Heart disease
OT  - Maternal outcomes
OT  - Neonatal outcome
OT  - Pregnancy
EDAT- 2015/05/07 06:00
MHDA- 2016/01/16 06:00
CRDT- 2015/05/07 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/10/19 00:00 [revised]
PHST- 2014/12/21 00:00 [accepted]
PHST- 2015/05/07 06:00 [entrez]
PHST- 2015/05/07 06:00 [pubmed]
PHST- 2016/01/16 06:00 [medline]
AID - S2210-7789(14)00439-5 [pii]
AID - 10.1016/j.preghy.2014.12.001 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2015 Apr;5(2):165-70. doi: 10.1016/j.preghy.2014.12.001. 
      Epub 2015 Jan 5.