PMID- 25943726
OWN - NLM
STAT- MEDLINE
DCOM- 20160531
LR  - 20181202
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 25
IP  - 2
DP  - 2016 Feb
TI  - Structural Differences in the Optic Nerve Head of Glaucoma Patients With and 
      Without Disc Hemorrhages.
PG  - e76-81
LID - 10.1097/IJG.0000000000000262 [doi]
AB  - PURPOSE: The aim of the study was to evaluate differences in planimetry, optic 
      nerve parameters, and visual field (VF) indices in glaucomatous eyes with a disc 
      hemorrhage (DH), their contralateral counterparts without DH, and normal 
      controls. PATIENTS AND METHODS: We retrospectively reviewed the records (from 
      1995 to 2013) of 44 glaucoma subjects with unilateral DH and 50 normal controls. 
      In the DH group, 33 had bilateral fundus photos for planimetric analysis 
      (Cyoptique GL), 15 had spectral domain-optical coherence tomography (SD-OCT), 15 
      had VF indices (Humphrey Visual Field Analyser), and 39 had >/= 5 perimetry outputs 
      for progression analysis (Progressor). RESULTS: Structurally, planimetric 
      analysis revealed that the eye with DH had a larger cup-disc ratio, more 
      significantly in the vertical aspect (P<0.001), and a thinner rim (P=0.010), 
      compared with the contralateral eye without DH. SD-OCT analysis also showed a 
      thinner rim area (P<0.001), most significantly in 2, 3, and 9 clock hours and the 
      inferior and superior quadrants (P<0.001) compared with the contralateral eye 
      without DH and normal controls. Also, the vertical cup-disc ratio was larger 
      (P<0.001). Functionally, VF deterioration was demonstrated by VF indices in eyes 
      with DH-mean deviation: -10.69 versus -0.97, P<0.001 and pattern standard 
      deviation: 6.60 versus 1.59, P<0.001, compared with normal controls. CONCLUSIONS: 
      Eyes with DH consistently displayed both structural features of more advanced 
      glaucoma confirmed simultaneously on planimetry and SD-OCT, with concurrent VF 
      deterioration.
FAU - Chin, You Chuen
AU  - Chin YC
AD  - *Singapore Eye Research Institute, Singapore National Eye Center daggerDepartment of 
      Ophthalmology, Yong Loo Lin School of Medicine double daggerDuke-NUS Graduate Medical School, 
      National University of Singapore, Singapore, Singapore.
FAU - Perera, Shamira A
AU  - Perera SA
FAU - Tun, Tin A
AU  - Tun TA
FAU - Teh, Gillian H
AU  - Teh GH
FAU - Cheung, Carol Y
AU  - Cheung CY
FAU - Aung, Tin
AU  - Aung T
FAU - Wong, Tien Yin
AU  - Wong TY
FAU - Baskaran, Mani
AU  - Baskaran M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Fundus Oculi
MH  - Glaucoma, Angle-Closure/*physiopathology
MH  - Glaucoma, Open-Angle/*physiopathology
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Retinal Hemorrhage/*physiopathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Visual Field Tests
MH  - Visual Fields/physiology
EDAT- 2015/05/07 06:00
MHDA- 2016/06/01 06:00
CRDT- 2015/05/07 06:00
PHST- 2015/05/07 06:00 [entrez]
PHST- 2015/05/07 06:00 [pubmed]
PHST- 2016/06/01 06:00 [medline]
AID - 10.1097/IJG.0000000000000262 [doi]
PST - ppublish
SO  - J Glaucoma. 2016 Feb;25(2):e76-81. doi: 10.1097/IJG.0000000000000262.