PMID- 25943983
OWN - NLM
STAT- MEDLINE
DCOM- 20160118
LR  - 20181113
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 8
DP  - 2015 May 6
TI  - Is there a role for monocyte chemoattractant protein-1 in delirium? Novel 
      observations in elderly hip fracture patients.
PG  - 186
LID - 10.1186/s13104-015-1129-5 [doi]
LID - 186
AB  - BACKGROUND: Delirium is common, associated with poor outcome, but its 
      pathophysiology remains obscure. The aim of the present study was to study a 
      possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of 
      delirium. FINDINGS: A prospective cohort of 19 hip fracture patients (median age 
      83 years) were screened for delirium daily by validated methods. MCP-1 was 
      measured on arrival and postoperatively. The number of patients with a raise in 
      MCP-1 was statistically significantly higher in the group with delirium in the 
      postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03). 
      CONCLUSIONS: MCP-1 might play a role in the development of delirium.
FAU - Skrede, Kjersti
AU  - Skrede K
AD  - Oslo Delirium Research Group, Oslo, Norway. kjersti.skrede@so-hf.no.
AD  - Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. 
      kjersti.skrede@so-hf.no.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway. kjersti.skrede@so-hf.no.
FAU - Wyller, Torgeir Bruun
AU  - Wyller TB
AD  - Oslo Delirium Research Group, Oslo, Norway. t.b.wyller@medisin.uio.no.
AD  - Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. 
      t.b.wyller@medisin.uio.no.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway. t.b.wyller@medisin.uio.no.
FAU - Watne, Leiv Otto
AU  - Watne LO
AD  - Oslo Delirium Research Group, Oslo, Norway. l.o.watne@gmail.com.
AD  - Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. 
      l.o.watne@gmail.com.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway. l.o.watne@gmail.com.
FAU - Seljeflot, Ingebjorg
AU  - Seljeflot I
AD  - Center for Clinical Heart Research, Oslo University Hospital, Oslo, Norway. 
      ingebjorg.seljeflot@ous-hf.no.
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway. 
      ingebjorg.seljeflot@ous-hf.no.
FAU - Juliebo, Vibeke
AU  - Juliebo V
AD  - Oslo Delirium Research Group, Oslo, Norway. v.juliebo@gmail.com.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway. v.juliebo@gmail.com.
AD  - Department of Cardiology, Oslo University Hospital, Oslo, Norway. 
      v.juliebo@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150506
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/*blood
MH  - Delirium/*blood
MH  - Female
MH  - Hip Fractures/*blood/surgery
MH  - Humans
MH  - Male
MH  - Postoperative Complications/etiology
MH  - Postoperative Period
MH  - Preoperative Care
PMC - PMC4428231
EDAT- 2015/05/07 06:00
MHDA- 2016/01/19 06:00
PMCR- 2015/05/06
CRDT- 2015/05/07 06:00
PHST- 2014/09/15 00:00 [received]
PHST- 2015/04/21 00:00 [accepted]
PHST- 2015/05/07 06:00 [entrez]
PHST- 2015/05/07 06:00 [pubmed]
PHST- 2016/01/19 06:00 [medline]
PHST- 2015/05/06 00:00 [pmc-release]
AID - 10.1186/s13104-015-1129-5 [pii]
AID - 1129 [pii]
AID - 10.1186/s13104-015-1129-5 [doi]
PST - epublish
SO  - BMC Res Notes. 2015 May 6;8:186. doi: 10.1186/s13104-015-1129-5.