PMID- 25944410 OWN - NLM STAT- MEDLINE DCOM- 20160802 LR - 20181113 IS - 1740-634X (Electronic) IS - 0893-133X (Print) IS - 0893-133X (Linking) VI - 40 IP - 12 DP - 2015 Nov TI - Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia. PG - 2705-14 LID - 10.1038/npp.2015.119 [doi] AB - The amplitude of low-frequency fluctuations (ALFF) in the blood oxygenation level-dependent (BOLD) signal during resting-state fMRI reflects the magnitude of local low-frequency BOLD oscillations, rather than interregional connectivity. ALFF is of interest to studies of cognition because fluctuations in spontaneous intrinsic brain activity relate to, and possibly even constrain, task-evoked brain responses in healthy people. Lower ALFF has been reported in schizophrenia, but the cognitive correlates of these reductions remain unknown. Here, we assess relationships between ALFF and attention and working memory in order to establish the functional relevance of intrinsic BOLD oscillatory power alterations with respect to specific cognitive impairments in schizophrenia. As part of the multisite FBIRN study, resting-state fMRI data were collected from schizophrenia subjects (SZ; n=168) and healthy controls (HC; n=166). Voxelwise fractional ALFF (fALFF), a normalized ALFF measure, was regressed on neuropsychological measures of sustained attention and working memory in SZ and HC to identify regions showing either common slopes across groups or slope differences between groups (all findings p<0.01 height, p<0.05 family-wise error cluster corrected). Poorer sustained attention was associated with smaller fALFF in the left superior frontal cortex and bilateral temporoparietal junction in both groups, with additional relationships in bilateral posterior parietal, posterior cingulate, dorsal anterior cingulate (ACC), and right dorsolateral prefrontal cortex (DLPFC) evident only in SZ. Poorer working memory was associated with smaller fALFF in bilateral ACC/mPFC, DLPFC, and posterior parietal cortex in both groups. Our findings indicate that smaller amplitudes of low-frequency BOLD oscillations during rest, measured by fALFF, were significantly associated with poorer cognitive performance, sometimes similarly in both groups and sometimes only in SZ, in regions known to subserve sustained attention and working memory. Taken together, these data suggest that the magnitude of resting-state BOLD oscillations shows promise as a biomarker of cognitive function in health and disease. FAU - Fryer, Susanna L AU - Fryer SL AD - Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. AD - San Francisco VA Medical Center, San Francisco, CA, USA. FAU - Roach, Brian J AU - Roach BJ AD - San Francisco VA Medical Center, San Francisco, CA, USA. FAU - Ford, Judith M AU - Ford JM AD - Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. AD - San Francisco VA Medical Center, San Francisco, CA, USA. FAU - Turner, Jessica A AU - Turner JA AD - The Mind Research Network, Albuquerque, NM, USA. FAU - van Erp, Theo G M AU - van Erp TG AD - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. FAU - Voyvodic, James AU - Voyvodic J AD - Department of Psychiatry, Duke University, Raleigh-Durham, NC, USA. FAU - Preda, Adrian AU - Preda A AUID- ORCID: 0000-0003-3373-2438 AD - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. FAU - Belger, Aysenil AU - Belger A AD - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. FAU - Bustillo, Juan AU - Bustillo J AD - Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA. FAU - O'Leary, Daniel AU - O'Leary D AD - Department of Psychiatry, University of Iowa, Iowa City, IA, USA. FAU - Mueller, Bryon A AU - Mueller BA AD - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. FAU - Lim, Kelvin O AU - Lim KO AD - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. FAU - McEwen, Sarah C AU - McEwen SC AD - Department of Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA. FAU - Calhoun, Vince D AU - Calhoun VD AD - The Mind Research Network, Albuquerque, NM, USA. AD - Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA. AD - Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA. FAU - Diaz, Michelle AU - Diaz M AD - Department of Psychiatry, Duke University, Raleigh-Durham, NC, USA. FAU - Glover, Gary AU - Glover G AD - Department of Radiology, Stanford University, Stanford, CA, USA. FAU - Greve, Douglas AU - Greve D AD - Department of Radiology, Massachusetts General Hospital, Boston, MA, USA. FAU - Wible, Cynthia G AU - Wible CG AD - Department of Psychiatry, Harvard University, Boston, MA, USA. AD - VA Boston Healthcare System, Brockton, MA, USA. FAU - Vaidya, Jatin AU - Vaidya J AD - Department of Psychiatry, University of Iowa, Iowa City, IA, USA. FAU - Potkin, Steven G AU - Potkin SG AD - Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. AD - San Francisco VA Medical Center, San Francisco, CA, USA. LA - eng GR - IK2 CX001028/CX/CSRD VA/United States GR - K01 MH099431/MH/NIMH NIH HHS/United States GR - U24 RR021992/RR/NCRR NIH HHS/United States GR - UL1 TR001449/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20150506 PL - England TA - Neuropsychopharmacology JT - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JID - 8904907 RN - 0 (Antipsychotic Agents) RN - S88TT14065 (Oxygen) SB - IM MH - Adult MH - Antipsychotic Agents/therapeutic use MH - Brain Waves/drug effects/*physiology MH - Cerebral Cortex/*blood supply/drug effects/pathology MH - Cognition Disorders/*etiology/*pathology MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neuropsychological Tests MH - Oxygen/blood MH - Psychiatric Status Rating Scales MH - Rest MH - Schizophrenia/*complications/drug therapy PMC - PMC4864646 EDAT- 2015/05/07 06:00 MHDA- 2016/08/03 06:00 PMCR- 2016/11/01 CRDT- 2015/05/07 06:00 PHST- 2014/10/29 00:00 [received] PHST- 2015/02/03 00:00 [revised] PHST- 2015/03/20 00:00 [accepted] PHST- 2015/05/07 06:00 [entrez] PHST- 2015/05/07 06:00 [pubmed] PHST- 2016/08/03 06:00 [medline] PHST- 2016/11/01 00:00 [pmc-release] AID - npp2015119 [pii] AID - 10.1038/npp.2015.119 [doi] PST - ppublish SO - Neuropsychopharmacology. 2015 Nov;40(12):2705-14. doi: 10.1038/npp.2015.119. Epub 2015 May 6.