PMID- 25947000 OWN - NLM STAT- MEDLINE DCOM- 20160411 LR - 20221207 IS - 1347-4820 (Electronic) IS - 1346-9843 (Linking) VI - 79 IP - 7 DP - 2015 TI - Comprehensive Risk Stratification of Japanese Patients With Aortic Stenosis--A Proposal of a New Risk Score From the CHART-2 Study. PG - 1631-8 LID - 10.1253/circj.CJ-15-0062 [doi] AB - BACKGROUND: The risk of patients with aortic stenosis (AS) should be stratified not only by AS severity but also by comorbidities. METHODS AND RESULTS: We aimed to develop a risk score for mortality in 412 patients with AS (pressure gradient >/=30 mmHg, mean age 74.9 years, male 52.4%) in the CHART-2 Study (n=10,219). During a 3-year follow-up, 73 (17.7%) patients died. Crude 3-year mortality of patients in New York Heart Association (NYHA) classes I, II, and III/IV was 9.5%, 16.5%, and 49.7%, respectively (P<0.001). Stepwise Cox regression analysis showed that the combination of 7 factors was the best model to predict the mortality of AS patients, who were scored according to their hazard ratios, including NYHA class III-IV (score 6), male sex (3), serum albumin level /=4.5 m/s (2), age >/=75 years (2), chronic kidney disease (2), and anemia (1). Receiver-operating characteristic analysis showed excellent association between the sum of the scores and 3-year mortality (area under the curve, 0.78). The multivariate Cox proportional hazard model demonstrated that the present risk score also well stratified the mortality risk. CONCLUSIONS: The present study demonstrates that, in addition to the classical prognostic factors related to symptoms and AS severity, various comorbidities are associated with mortality. Thus, the present comprehensive risk score may be useful for risk stratification of AS patients. FAU - Sato, Kenjiro AU - Sato K AD - Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine. FAU - Sakata, Yasuhiko AU - Sakata Y FAU - Miura, Masanobu AU - Miura M FAU - Tadaki, Soichiro AU - Tadaki S FAU - Ushigome, Ryoichi AU - Ushigome R FAU - Yamauchi, Takeshi AU - Yamauchi T FAU - Onose, Takeo AU - Onose T FAU - Tsuji, Kanako AU - Tsuji K FAU - Abe, Ruri AU - Abe R FAU - Nochioka, Kotaro AU - Nochioka K FAU - Takahashi, Jun AU - Takahashi J FAU - Miyata, Satoshi AU - Miyata S FAU - Shimokawa, Hiroaki AU - Shimokawa H CN - CHART-2 Investigators LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20150501 PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 SB - IM CIN - Circ J. 2015;79(7):1458-9. PMID: 26040295 MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Aortic Valve Stenosis/*mortality/physiopathology MH - Asian People MH - Female MH - Follow-Up Studies MH - Humans MH - Japan/epidemiology MH - Male MH - Proportional Hazards Models MH - Prospective Studies MH - Risk Assessment MH - Sex Factors FIR - Shimokawa, Hiroaki IR - Shimokawa H FIR - Goto, Toshikazu IR - Goto T FIR - Nozaki, Eiji IR - Nozaki E FIR - Hiramoto, Tetsuya IR - Hiramoto T FIR - Fukuchi, Mitsumasa IR - Fukuchi M FIR - Inoue, Kanichi IR - Inoue K FIR - Kato, Atsushi IR - Kato A FIR - Sugi, Masafumi IR - Sugi M FIR - Ohe, Masatoshi IR - Ohe M FIR - Shinozaki, Tsuyoshi IR - Shinozaki T FIR - Horiguchi, Satoru IR - Horiguchi S FIR - Kato, Hiroshi IR - Kato H FIR - Inoue, Kanichi IR - Inoue K FIR - Hiramoto, Tetsuya IR - Hiramoto T FIR - Ogata, Masahiko IR - Ogata M FIR - Kato, Atsushi IR - Kato A FIR - Sato, Shoichi IR - Sato S FIR - Sugi, Masafumi IR - Sugi M FIR - Oyama, Shigeto IR - Oyama S FIR - Nozaki, Eiji IR - Nozaki E FIR - Nakamura, Akihiro IR - Nakamura A FIR - Takahashi, Tohru IR - Takahashi T FIR - Endo, Hideaki IR - Endo H FIR - Fukui, Shigefumi IR - Fukui S FIR - Nakajima, Sota IR - Nakajima S FIR - Nakagawa, Makoto IR - Nakagawa M FIR - Nozaki, Tetsuji IR - Nozaki T FIR - Yagi, Takuya IR - Yagi T FIR - Horiguchi, Satoru IR - Horiguchi S FIR - Fushimi, Etsuko IR - Fushimi E FIR - Sugai, Yoshinao IR - Sugai Y FIR - Takeda, Satoru IR - Takeda S FIR - Fukahori, Kouhei IR - Fukahori K FIR - Aizawa, Kentaro IR - Aizawa K FIR - Ohe, Masatoshi IR - Ohe M FIR - Tashima, Takurou IR - Tashima T FIR - Sakurai, Katsuhiko IR - Sakurai K FIR - Kobayashi, Tadashi IR - Kobayashi T FIR - Goto, Toshikazu IR - Goto T FIR - Matsui, Motoyuki IR - Matsui M FIR - Tamada, Yoshiaki IR - Tamada Y FIR - Yahagi, Tomoyasu IR - Yahagi T FIR - Fukui, Akio IR - Fukui A FIR - Takahashi, Katsuaki IR - Takahashi K FIR - Kikuchi, Yoku IR - Kikuchi Y FIR - Sugimura, Akihiko IR - Sugimura A FIR - Ohashi, Junko IR - Ohashi J FIR - 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Fukuchi M FIR - Ogata, Masahiko IR - Ogata M FIR - Tanikawa, Toshinori IR - Tanikawa T FIR - Kitamukai, Osamu IR - Kitamukai O FIR - Matsumoto, Yasuharu IR - Matsumoto Y FIR - Inoue, Kanichi IR - Inoue K FIR - Koyama, Jiro IR - Koyama J FIR - Tomioka, Tomoko IR - Tomioka T FIR - Shioiri, Hiroki IR - Shioiri H FIR - Ito, Yoshitaka IR - Ito Y FIR - Kato, Hiroshi IR - Kato H FIR - Takahashi, Chikako IR - Takahashi C FIR - Kawana, Akiko IR - Kawana A FIR - Sakata, Yasuhiko IR - Sakata Y FIR - Ito, Kenta IR - Ito K FIR - Nakayama, Masaharu IR - Nakayama M FIR - Fukuda, Koji IR - Fukuda K FIR - Takahashi, Jun IR - Takahashi J FIR - Miyata, Satoshi IR - Miyata S FIR - Sugimura, Koichiro IR - Sugimura K FIR - Sato, Kimio IR - Sato K FIR - Matsumoto, Yasuharu IR - Matsumoto Y FIR - Nakano, Makoto IR - Nakano M FIR - Shiroto, Takashi IR - Shiroto T FIR - Tsuburaya, Ryuji IR - Tsuburaya R FIR - Nochioka, Kotaro IR - Nochioka K FIR - Yamamoto, Hiroaki IR - Yamamoto H FIR - Aoki, Tatsuo IR - Aoki T FIR - Hao, Kiyotaka IR - Hao K FIR - Miura, Masanobu IR - Miura M FIR - Kondo, Masaki IR - Kondo M FIR - Tatebe, Shunsuke IR - Tatebe S FIR - Yamamoto, Saori IR - Yamamoto S FIR - Suzuki, Hideaki IR - Suzuki H FIR - Nishimiya, Kensuke IR - Nishimiya K FIR - Yaoita, Nobuhiro IR - Yaoita N FIR - Sugi, Masafumi IR - Sugi M FIR - Yamamoto, Yoshito IR - Yamamoto Y FIR - Toda, Sunao IR - Toda S FIR - Minatoya, Yutaka IR - Minatoya Y FIR - Takagi, Yusuke IR - Takagi Y FIR - Hasebe, Yuhi IR - Hasebe Y FIR - Nihei, Taro IR - Nihei T FIR - Fukuda, Koji IR - Fukuda K FIR - Sakata, Yasuhiko IR - Sakata Y FIR - Fukumoto, Yoshihiro IR - Fukumoto Y FIR - Takahashi, Jun IR - Takahashi J FIR - Miyata, Satoshi IR - Miyata S FIR - Nochioka, Kotaro IR - Nochioka K FIR - Miura, Masanobu IR - Miura M FIR - Tadaki, Soichiro IR - Tadaki S FIR - Ushigome, Ryoichi IR - Ushigome R FIR - Yamauchi, Takeshi IR - Yamauchi T FIR - Sato, Kenjiro IR - Sato K FIR - Tsuji, Kanako IR - Tsuji K FIR - Onose, Takeo IR - Onose T FIR - Abe, Ruri IR - Abe R FIR - Saga, Chiharu IR - Saga C FIR - Suenaga, Junko IR - Suenaga J FIR - Yamada, Yoko IR - Yamada Y FIR - Kimura, Junko IR - Kimura J FIR - Ogino, Hiromi IR - Ogino H FIR - Oikawa, Izumi IR - Oikawa I FIR - Watanabe, Sanae IR - Watanabe S FIR - Saga, Madoka IR - Saga M FIR - Washio, Miki IR - Washio M FIR - Nagasawa, Keiko IR - Nagasawa K FIR - Nagasawa, Sachiko IR - Nagasawa S FIR - Kotaka, Sachie IR - Kotaka S FIR - Komatsu, Wakiko IR - Komatsu W FIR - Hashimoto, Reiko IR - Hashimoto R FIR - Ikeno, Yasuko IR - Ikeno Y FIR - Suzuki, Tomoyuki IR - Suzuki T FIR - Hamada, Hiroko IR - Hamada H EDAT- 2015/05/08 06:00 MHDA- 2016/04/12 06:00 CRDT- 2015/05/08 06:00 PHST- 2015/05/08 06:00 [entrez] PHST- 2015/05/08 06:00 [pubmed] PHST- 2016/04/12 06:00 [medline] AID - 10.1253/circj.CJ-15-0062 [doi] PST - ppublish SO - Circ J. 2015;79(7):1631-8. doi: 10.1253/circj.CJ-15-0062. Epub 2015 May 1.