PMID- 25947037
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 57
IP  - 2
DP  - 2016 Feb
TI  - Change of health-related profiles after Imatinib cessation in chronic phase 
      chronic myeloid leukemia patients.
PG  - 341-347
LID - 10.3109/10428194.2015.1049166 [doi]
AB  - The aim of this study was to investigate the changes in health-related profiles 
      including quality-of-life (HRQoL) in the chronic myeloid leukemia (CML) patients 
      who discontinued imatinib (IM). An HRQoL survey composed of 43 parameters about 
      IM-related adverse events (AEs), physical health-related and mental 
      health-related was provided at baseline and 6 months post-discontinuation. A 
      total of 55 patients with a sustained UMRD over 6 months were analyzed. Although 
      the majority of IM-related AEs were significantly improved, unexpectedly pruritus 
      and musculoskeletal pain worsen or newly develop in 29.1% and 21.8% of patients, 
      respectively. The improvements in physical and mental health condition were 
      variable in individual patients. In addition, rapid restorations of the 
      hematological and biochemical parameters were observed. The results showed the 
      changes of HRQoL and laboratory tests in treatment-off patients and the necessity 
      of continuing physical and mental support for some patients in tyrosine kinase 
      inhibitor (TKI)-off studies.
FAU - Park, Joon Seong
AU  - Park JS
AD  - a Department of Hematology-Oncology , Ajou University School of Medicine , Suwon 
      , Korea.
FAU - Lee, Sung-Eun
AU  - Lee SE
AD  - b Department of Hematology , Seoul St Mary's Hospital, The Catholic University of 
      Korea , Seoul , Korea.
FAU - Jeong, Seong Hyun
AU  - Jeong SH
AD  - a Department of Hematology-Oncology , Ajou University School of Medicine , Suwon 
      , Korea.
FAU - Jang, Eun-Jung
AU  - Jang EJ
AD  - b Department of Hematology , Seoul St Mary's Hospital, The Catholic University of 
      Korea , Seoul , Korea.
FAU - Choi, Mi-Yeon
AU  - Choi MY
AD  - b Department of Hematology , Seoul St Mary's Hospital, The Catholic University of 
      Korea , Seoul , Korea.
FAU - Kim, Hyeoung-Joon
AU  - Kim HJ
AD  - c Department of Hematology-Oncology , Chonnam National University Hwasun, 
      Hospital , Hwasun , Korea.
FAU - Kim, Yeo-Kyeoung
AU  - Kim YK
AD  - c Department of Hematology-Oncology , Chonnam National University Hwasun, 
      Hospital , Hwasun , Korea.
FAU - Kim, Sung-Hyun
AU  - Kim SH
AD  - d Department of Internal Medicine , Dong-A University College of Medicine , Busan 
      , Korea.
FAU - Zang, Dae Young
AU  - Zang DY
AD  - e Department of Internal Medicine , Hallym University College of Medicine , 
      Anyang , Korea.
FAU - Oh, Sukjoong
AU  - Oh S
AD  - f Division of Hematology-Oncology, Department of Internal Medicine , Kangbuk 
      Samsung Hospital, School of Medicine, Sungkyunkwan University , Seoul , Korea.
FAU - Koo, Dong Hoe
AU  - Koo DH
AD  - f Division of Hematology-Oncology, Department of Internal Medicine , Kangbuk 
      Samsung Hospital, School of Medicine, Sungkyunkwan University , Seoul , Korea.
FAU - Kim, Hawk
AU  - Kim H
AD  - g Division of Hematology and Cellular Therapy, Ulsan University Hospital, 
      University of Ulsan College of Medicine , Ulsan , Korea.
FAU - Do, Young Rok
AU  - Do YR
AD  - h Division of Hematology-Oncology, School of Medicine, Keimyung University , 
      Daegu , Korea.
FAU - Kwak, Jae-Yong
AU  - Kwak JY
AD  - i Division of Hematology-Oncology, Chonbuk National University Medical School , 
      Jeonju , Korea.
FAU - Kim, Jeong-A
AU  - Kim JA
AD  - j Department of Hematology , St Vincent's Hospital, The Catholic University of 
      Korea , Suwon , Korea.
FAU - Kim, Dae-Young
AU  - Kim DY
AD  - k Department of Hematology , Asan Medical Center, University of Ulsan College of 
      Medicine , Seoul , Korea.
FAU - Mun, Yeung-Chul
AU  - Mun YC
AD  - l Department of Hematology , School of Medicine, Ewha Womans University , Seoul , 
      Korea.
FAU - Lee, Won Sik
AU  - Lee WS
AD  - m Department of Internal Medicine , Inje University College of Medicine, Inje 
      University Busan Paik Hospital , Busan , Korea.
FAU - Chang, Myung Hee
AU  - Chang MH
AD  - n Department of Hematology-Oncology , National Health Insurance Service Ilsan 
      Hospital , Ilsan , Korea.
FAU - Park, Jinny
AU  - Park J
AD  - o Department of Hematology , Gachon University Gil Hospital , Incheon , Korea.
FAU - Kwon, Ji Hyun
AU  - Kwon JH
AD  - p Department of Hematology-Oncology , Chungbuk National University Hospital , 
      Cheongju , Korea.
FAU - Kim, Dong-Wook
AU  - Kim DW
AD  - b Department of Hematology , Seoul St Mary's Hospital, The Catholic University of 
      Korea , Seoul , Korea.
LA  - eng
PT  - Journal Article
DEP - 20150612
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
OTO - NOTNLM
OT  - Chronic myeloid leukemia
OT  - imatinib cessation
OT  - quality-of-life
EDAT- 2015/05/08 06:00
MHDA- 2015/05/08 06:01
CRDT- 2015/05/08 06:00
PHST- 2015/05/08 06:00 [pubmed]
PHST- 2015/05/08 06:01 [medline]
PHST- 2015/05/08 06:00 [entrez]
AID - 10.3109/10428194.2015.1049166 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2016 Feb;57(2):341-347. doi: 10.3109/10428194.2015.1049166. Epub 
      2015 Jun 12.