PMID- 25947167 OWN - NLM STAT- MEDLINE DCOM- 20151204 LR - 20220331 IS - 1472-6882 (Electronic) IS - 1472-6882 (Linking) VI - 15 DP - 2015 May 7 TI - Electroacupuncture analgesia is associated with increased serum brain-derived neurotrophic factor in chronic tension-type headache: a randomized, sham controlled, crossover trial. PG - 144 LID - 10.1186/s12906-015-0664-x [doi] LID - 144 AB - BACKGROUND: Chronic tension-type headache (CTTH) is characterized by almost daily headaches and central sensitization, for which electroacupuncture (EA) might be effective. The central nervous system (CNS) plasticity can be tracked in serum using the brain-derived neurotrophic factor (BDNF), a neuroplasticity mediator. Thus, we tested the hypothesis that EA analgesia in CTTH is related to neuroplasticity indexed by serum BDNF. METHODS: We enrolled females aged 18-60 years with CTTH in a randomized, blinded, placebo-controlled crossover trial, comparing ten EA sessions applied for 30 minutes (2-10 Hz, intensity by tolerance) in cervical areas twice per week vs. a sham intervention. Treatment periods were separated by two washout weeks. Pain on the 10-cm visual analog scale (VAS) and serum BDNF were assessed as primary outcomes. RESULTS: Thirty-four subjects underwent randomization, and twenty-nine completed the protocol. EA was superior to sham to alleviate pain (VAS scores 2.38 +/- 1.77 and 3.02 +/- 2.49, respectively, P = 0.005). The VAS scores differed according to the intervention sequence, demonstrating a carryover effect (P < 0.05). Using multiple regression, serum BDNF was adjusted for the Hamilton depression rating scale (HDRS) and the VAS scores (r-squared = 0.07, standard beta coefficients = -0.2 and -0.14, respectively, P < 0.001). At the end of the first intervention period, the adjusted BDNF was higher in the EA phase (29.31 +/- 3.24, 27.53 +/- 2.94 ng/mL, Cohen's d = 0.55). CONCLUSION: EA analgesia is related to neuroplasticity indexed by the adjusted BDNF. EA modulation of pain and BDNF occurs according to the CNS situation at the moment of its administration, as it was related to depression and the timing of its administration. FAU - Chassot, Monica AU - Chassot M AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. monicachassot@hotmail.com. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. monicachassot@hotmail.com. FAU - Dussan-Sarria, Jairo Alberto AU - Dussan-Sarria JA AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. jadussans@gmail.com. AD - Pain and Palliative Care Service at Hospital de Clinicas de Porto Alegre (HCPA), UFRGS, Porto Alegre, Brazil. jadussans@gmail.com. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. jadussans@gmail.com. FAU - Sehn, Francislea Cristina AU - Sehn FC AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. francisehn@ibest.com.br. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. francisehn@ibest.com.br. FAU - Deitos, Alicia AU - Deitos A AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. aliciadeitos@gmail.com. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. aliciadeitos@gmail.com. FAU - de Souza, Andressa AU - de Souza A AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. andressasz@gmail.com. AD - Post-Graduate Program in Health and Human Development, Unilasalle Universitary Center, Canoas, Brazil. andressasz@gmail.com. FAU - Vercelino, Rafael AU - Vercelino R AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. rvercelino@gmail.com. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. rvercelino@gmail.com. FAU - Torres, Iraci L S AU - Torres IL AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. iracitorres@gmail.com. AD - Pharmacology Department, Instituto de Ciencias Basicas da Saude, UFRGS, Porto Alegre, Brazil. iracitorres@gmail.com. FAU - Fregni, Felipe AU - Fregni F AD - Spaulding Center of Neuromodulation, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA. felipe.fregni@gmail.com. FAU - Caumo, Wolnei AU - Caumo W AD - Post-Graduate Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. caumo@cpovo.net. AD - Pain and Palliative Care Service at Hospital de Clinicas de Porto Alegre (HCPA), UFRGS, Porto Alegre, Brazil. caumo@cpovo.net. AD - Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre at UFRGS, Rua Ramiro Barcelos, 2350 - CEP 90035-003 Bairro Rio Branco, Porto, Brazil. caumo@cpovo.net. AD - Surgery Department, School of Medicine at UFRGS, Porto Alegre, Brazil. caumo@cpovo.net. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150507 PL - England TA - BMC Complement Altern Med JT - BMC complementary and alternative medicine JID - 101088661 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - *Acupuncture Analgesia MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Central Nervous System/physiology MH - Cross-Over Studies MH - Depression/complications MH - *Electroacupuncture MH - Female MH - Humans MH - Middle Aged MH - Pain Management/*methods MH - Pain Measurement MH - Tension-Type Headache/blood/*therapy PMC - PMC4429917 EDAT- 2015/05/08 06:00 MHDA- 2015/12/15 06:00 PMCR- 2015/05/07 CRDT- 2015/05/08 06:00 PHST- 2014/06/28 00:00 [received] PHST- 2015/04/28 00:00 [accepted] PHST- 2015/05/08 06:00 [entrez] PHST- 2015/05/08 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] PHST- 2015/05/07 00:00 [pmc-release] AID - 10.1186/s12906-015-0664-x [pii] AID - 664 [pii] AID - 10.1186/s12906-015-0664-x [doi] PST - epublish SO - BMC Complement Altern Med. 2015 May 7;15:144. doi: 10.1186/s12906-015-0664-x.