PMID- 25948071
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 17
IP  - 1
DP  - 2015 May 7
TI  - Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical 
      phenotype.
PG  - 115
LID - 10.1186/s13075-015-0640-3 [doi]
LID - 115
AB  - This review focuses on the genetic features of psoriatic arthritis (PsA) and 
      their relationship to phenotypic heterogeneity in the disease, and addresses 
      three questions: what do the recent studies on human leukocyte antigen (HLA) tell 
      us about the genetic relationship between cutaneous psoriasis (PsO) and PsA - 
      that is, is PsO a unitary phenotype; is PsA a genetically heterogeneous or 
      homogeneous entity; and do the genetic factors implicated in determining 
      susceptibility to PsA predict clinical phenotype? We first discuss the results 
      from comparing the HLA typing of two PsO cohorts: one cohort providing the 
      dermatologic perspective, consisting of patients with PsO without evidence of 
      arthritic disease; and the second cohort providing the rheumatologic perspective, 
      consisting of patients with PsA. We show that these two cohorts differ 
      considerably in their predominant HLA alleles, indicating the heterogeneity of 
      the overall PsO phenotype. Moreover, the genotype of patients in the PsA cohort 
      was shown to be heterogeneous with significant elevations in the frequency of 
      haplotypes containing HLA-B*08, HLA-C*06:02, HLA-B*27, HLA-B*38 and HLA-B*39. 
      Because different genetic susceptibility genes imply different disease 
      mechanisms, and possibly different clinical courses and therapeutic responses, we 
      then review the evidence for a phenotypic difference among patients with PsA who 
      have inherited different HLA alleles. We provide evidence that different alleles 
      and, more importantly, different haplotypes implicated in determining PsA 
      susceptibility are associated with different phenotypic characteristics that 
      appear to be subphenotypes. The implication of these findings for the overall 
      pathophysiologic mechanisms involved in PsA is discussed with specific reference 
      to their bearing on the discussion of whether PsA is conceptualised as an 
      autoimmune process or one that is based on entheseal responses.
FAU - FitzGerald, Oliver
AU  - FitzGerald O
AD  - Department of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin, 
      4, Ireland. oliver.fitzgerald@ucd.ie.
FAU - Haroon, Muhammad
AU  - Haroon M
AD  - Department of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin, 
      4, Ireland. mharoon301@hotmail.com.
FAU - Giles, Jon T
AU  - Giles JT
AD  - Rheumatology Division, Department of Medicine, Columbia University College of 
      Physicians and Surgeons, 630 West 168th Street, New York City, NY, 10032, USA. 
      jtg2122@columbia.edu.
FAU - Winchester, Robert
AU  - Winchester R
AD  - Rheumatology Division, Department of Medicine, Columbia University College of 
      Physicians and Surgeons, 630 West 168th Street, New York City, NY, 10032, USA. 
      rjw8@columbia.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150507
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Arthritis, Psoriatic/*genetics/immunology/*physiopathology
MH  - Female
MH  - Gene Expression Regulation
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - *Genotype
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prognosis
MH  - Severity of Illness Index
PMC - PMC4422545
EDAT- 2015/05/08 06:00
MHDA- 2016/01/20 06:00
PMCR- 2015/05/07
CRDT- 2015/05/08 06:00
PHST- 2015/05/08 06:00 [entrez]
PHST- 2015/05/08 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2015/05/07 00:00 [pmc-release]
AID - 10.1186/s13075-015-0640-3 [pii]
AID - 640 [pii]
AID - 10.1186/s13075-015-0640-3 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2015 May 7;17(1):115. doi: 10.1186/s13075-015-0640-3.