PMID- 25948074
OWN - NLM
STAT- MEDLINE
DCOM- 20160425
LR  - 20181113
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 49
IP  - 3
DP  - 2015 Aug
TI  - Associations between a common variant near the MC4R gene and serum triglyceride 
      levels in an obese pediatric cohort.
PG  - 653-8
LID - 10.1007/s12020-015-0616-8 [doi]
AB  - Polymorphisms near the MC4R gene may be related to an increased risk for obesity, 
      but studies of variations in this gene and its relation to cardiometabolic 
      profiles and food intake are scarce and controversial. The aim of this study is 
      to evaluate the influence of the variants rs12970134 and rs17782313 near the MC4R 
      gene in food intake, binge eating (BE) behavior, anthropometric parameters, body 
      composition, metabolic profile, and cardiometabolic risk factors in obese 
      children and adolescents. This is a cross-sectional study that included obese 
      children and adolescents. We evaluated anthropometric, metabolic parameters and 
      cardiometabolic risk factors, including hypertension, impaired fasting glucose, 
      hypertriglyceridemia, and low HDL-cholesterol. BE was assessed through the BE 
      scale, and a 24-h recall was used to evaluate total caloric intake and percentage 
      of macronutrients and types of dietary fat. The MC4R variants rs12970134 and 
      rs17782313 were genotyped using TaqMan assay. To assess the magnitude of risk, a 
      logistic regression adjusted for Z-BMI, age, and gender was performed, adopting 
      the significance level of 0.05. The study included 518 subjects (52.1 % girls, 
      12.7 +/- 2.7 years old, Z-BMI = 3.24 +/- 0.57). Carriers of the variant rs17782313 
      exhibit increased triglyceride levels (108 +/- 48 vs. 119 +/- 54, p = 0.034) and an 
      increased risk of hypertriglyceridemia (OR 1.985, 95 % CI 1.288-3.057, p = 
      0.002). There was no association of the SNP rs12970134 with clinical, metabolic, 
      or nutritional parameters. The variant rs12970134 and rs17782313 did not 
      influence food intake or the presence of BE. The variant rs17782313 is associated 
      with an increased risk of hypertriglyceridemia in obese children and adolescents.
FAU - Fernandes, Ariana Ester
AU  - Fernandes AE
AD  - League of Childhood Obesity, Service of Endocrinology and Metabolism, Faculty of 
      Medicine, Hospital das Clinicas, University of Sao Paulo, Av. Dr. Eneas de 
      Carvalho Aguiar, 255, 7 masculine andar, sala 7037, Sao Paulo, SP, 05403-000, Brazil, 
      ariana@usp.br.
FAU - de Melo, Maria Edna
AU  - de Melo ME
FAU - Fujiwara, Clarissa Tamie Hiwatashi
AU  - Fujiwara CT
FAU - Pioltine, Marina Brosso
AU  - Pioltine MB
FAU - Matioli, Sergio Russo
AU  - Matioli SR
FAU - Santos, Aritania
AU  - Santos A
FAU - Cercato, Cintia
AU  - Cercato C
FAU - Halpern, Alfredo
AU  - Halpern A
FAU - Mancini, Marcio C
AU  - Mancini MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150507
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (MC4R protein, human)
RN  - 0 (Receptor, Melanocortin, Type 4)
RN  - 0 (Triglycerides)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Anthropometry
MH  - Binge-Eating Disorder/genetics/psychology
MH  - Body Composition/genetics
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - DNA/genetics
MH  - Eating/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Variation
MH  - Humans
MH  - Male
MH  - Obesity/*blood/*genetics/psychology
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptor, Melanocortin, Type 4/*genetics
MH  - Risk Factors
MH  - Triglycerides/*blood
MH  - Young Adult
EDAT- 2015/05/08 06:00
MHDA- 2016/04/26 06:00
CRDT- 2015/05/08 06:00
PHST- 2015/01/30 00:00 [received]
PHST- 2015/04/21 00:00 [accepted]
PHST- 2015/05/08 06:00 [entrez]
PHST- 2015/05/08 06:00 [pubmed]
PHST- 2016/04/26 06:00 [medline]
AID - 10.1007/s12020-015-0616-8 [doi]
PST - ppublish
SO  - Endocrine. 2015 Aug;49(3):653-8. doi: 10.1007/s12020-015-0616-8. Epub 2015 May 7.