PMID- 25948793
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181113
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 7
IP  - 4
DP  - 2015 Apr
TI  - Caloric restriction induces heat shock response and inhibits B16F10 cell 
      tumorigenesis both in vitro and in vivo.
PG  - 233-40
AB  - Caloric restriction (CR) without malnutrition is one of the most consistent 
      strategies for increasing mean and maximal lifespan and delaying the onset of 
      age-associated diseases. Stress resistance is a common trait of many long-lived 
      mutants and life-extending interventions, including CR. Indeed, better protection 
      against heat shock and other genotoxic insults have helped explain the 
      pro-survival properties of CR. In this study, both in vitro and in vivo responses 
      to heat shock were investigated using two different models of CR. Murine B16F10 
      melanoma cells treated with serum from CR-fed rats showed lower proliferation, 
      increased tolerance to heat shock and enhanced HSP-70 expression, compared to 
      serum from ad libitum-fed animals. Similar effects were observed in B16F10 cells 
      implanted subcutaneously in male C57BL/6 mice subjected to CR. Microarray 
      analysis identified a number of genes and pathways whose expression profile were 
      similar in both models. These results suggest that the use of an in vitro model 
      could be a good alternative to study the mechanisms by which CR exerts its 
      anti-tumorigenic effects.
FAU - Novelle, Marta G
AU  - Novelle MG
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
AD  - Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto 
      de Investigacion Sanitaria, 15782 Santiago de Compostela, Spain; CIBER 
      Fisiopatologia de la Obesidad y Nutricion (CIBERobn), 15706 Santiago de 
      Compostela, Spain.
FAU - Davis, Ashley
AU  - Davis A
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Price, Nathan L
AU  - Price NL
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Ali, Ahmed
AU  - Ali A
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Furer-Galvan, Stefanie
AU  - Furer-Galvan S
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Zhang, Yongqing
AU  - Zhang Y
AD  - Gene Expression and Genomics Unit, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Becker, Kevin
AU  - Becker K
AD  - Gene Expression and Genomics Unit, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - Bernier, Michel
AU  - Bernier M
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
FAU - de Cabo, Rafael
AU  - de Cabo R
AD  - Translational Gerontology Branch, National Institute on Aging, National 
      Institutes of Health, Baltimore, MD 21224, USA.
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (HSP70 Heat-Shock Proteins)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Carcinogenesis/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/physiology
MH  - Energy Intake/physiology
MH  - HSP70 Heat-Shock Proteins/*metabolism
MH  - Heat-Shock Response/*physiology
MH  - Male
MH  - Mice
MH  - Rats
PMC - PMC4429088
COIS- Conflict of interest statement The authors have no conflict of interests to 
      declare.
EDAT- 2015/05/08 06:00
MHDA- 2016/02/03 06:00
PMCR- 2015/04/01
CRDT- 2015/05/08 06:00
PHST- 2015/05/08 06:00 [entrez]
PHST- 2015/05/08 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 100732 [pii]
AID - 10.18632/aging.100732 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2015 Apr;7(4):233-40. doi: 10.18632/aging.100732.