PMID- 25950609 OWN - NLM STAT- MEDLINE DCOM- 20160527 LR - 20221207 IS - 1945-0257 (Electronic) IS - 1945-0257 (Linking) VI - 19 IP - 7 DP - 2015 Jul TI - Association between BDNF gene polymorphisms and attention deficit hyperactivity disorder in Korean children. PG - 366-71 LID - 10.1089/gtmb.2015.0029 [doi] AB - BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder characterized by behavioral problems such as attention deficit, hyperactivity, and impulsivity. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the brain. AIMS: The aim of the present study was to investigate the association between the genotype and alleles for the BDNF gene in Korean children with ADHD. METHODS: The sample consisted of 180 ADHD children and 159 control children. We diagnosed ADHD according to the DSM-IV. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 339 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for BDNF rs6265, rs11030101, rs10835210, rs7103873, and rs2030324 polymorphisms. Alleles and genotype frequencies were compared using the Chi-square test. We compared the allele and genotype frequencies of the BDNF gene polymorphism in the ADHD and control groups. RESULTS: This study showed that there was a significant correlation among the allele frequencies of the rs11030101 and rs10835210 single nucleotide polymorphisms (SNPs) (odds ratio=0.61, 95% confidence interval=0.39-0.96, p=0.034), but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggest that the BDNF allelic structure may impact ADHD symptoms. FAU - Kwon, Ho Jang AU - Kwon HJ AD - 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea . AD - 2 Department of Preventive Medicine, College of Medicine, Dankook University , Cheonan, South Korea . FAU - Ha, Mina AU - Ha M AD - 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea . AD - 2 Department of Preventive Medicine, College of Medicine, Dankook University , Cheonan, South Korea . FAU - Jin, Han Jun AU - Jin HJ AD - 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea . AD - 3 Department of Nanobiotics, College of Natural Science, Dankook University , Cheonan, South Korea . FAU - Hyun, Jung Keun AU - Hyun JK AD - 4 Department of Rehabilitation Medicine, College of Medicine, Dankook University , Cheonan, South Korea . AD - 5 Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan, South Korea . FAU - Shim, Se Hoon AU - Shim SH AD - 6 Department of Psychiatry, College of Medicine, Soonchunhyang University , Cheonan, South Korea . FAU - Paik, Ki Chung AU - Paik KC AD - 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea . AD - 7 Department of Psychiatry, College of Medicine, Dankook University , Cheonan, South Korea . FAU - Park, Woo Sung AU - Park WS AD - 8 Department of Pediatrics, College of Medicine, Dankook University , Cheonan, South Korea . FAU - Lim, Myung Ho AU - Lim MH AD - 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea . AD - 9 Department of Psychology, College of Public Welfare, Dankook University , Cheonan, South Korea . LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150507 PL - United States TA - Genet Test Mol Biomarkers JT - Genetic testing and molecular biomarkers JID - 101494210 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Asian People MH - Attention Deficit Disorder with Hyperactivity/*genetics MH - Brain-Derived Neurotrophic Factor/blood/*genetics MH - Case-Control Studies MH - Child MH - Female MH - Gene Frequency/genetics MH - Genetic Association Studies MH - Humans MH - Male MH - Odds Ratio MH - Polymorphism, Single Nucleotide MH - Republic of Korea MH - Surveys and Questionnaires EDAT- 2015/05/08 06:00 MHDA- 2016/05/28 06:00 CRDT- 2015/05/08 06:00 PHST- 2015/05/08 06:00 [entrez] PHST- 2015/05/08 06:00 [pubmed] PHST- 2016/05/28 06:00 [medline] AID - 10.1089/gtmb.2015.0029 [doi] PST - ppublish SO - Genet Test Mol Biomarkers. 2015 Jul;19(7):366-71. doi: 10.1089/gtmb.2015.0029. Epub 2015 May 7.