PMID- 25950822
OWN - NLM
STAT- MEDLINE
DCOM- 20151029
LR  - 20181113
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 88
IP  - 1051
DP  - 2015 Jul
TI  - Variation in patient position and impact on carbon-ion scanning beam distribution 
      during prostate treatment.
PG  - 20140623
LID - 10.1259/bjr.20140623 [doi]
LID - 20140623
AB  - OBJECTIVE: We assessed the impact of changes in patient position on carbon-ion 
      scanning beam distribution during treatment for prostate cancer. METHODS: 68 
      patients were selected. Carbon-ion scanning dose was calculated. Two different 
      planning target volumes (PTVs) were defined: PTV1 was the clinical target volume 
      plus a set-up margin for the anterior/lateral sides and posterior side, while 
      PTV2 was the same as PTV1 minus the posterior side. Total prescribed doses of 
      34.4 Gy [relative biological effectiveness (RBE)] and 17.2 Gy (RBE) were given to 
      PTV1 and PTV2, respectively. To estimate the influence of geometric variations on 
      dose distribution, the dose was recalculated on the rigidly shifted single 
      planning CT based on two dimensional-three dimensional rigid registration of the 
      orthogonal radiographs before and after treatment for the fraction of maximum 
      positional changes. RESULTS: Intrafractional patient positional change values 
      averaged over all patients throughout the treatment course were less than the 
      target registration error = 2.00 mm and angular error = 1.27 degrees . However, these 
      maximum positional errors did not occur in all 12 treatment fractions. Even 
      though large positional changes occurred during irradiation in all treatment 
      fractions, lowest dose encompassing 95% of the target (D95)-PTV1 was >98% of the 
      prescribed dose. CONCLUSION: Intrafractional patient positional changes occurred 
      during treatment beam irradiation and degraded carbon-ion beam dose distribution. 
      Our evaluation did not consider non-rigid deformations, however, dose 
      distribution was still within clinically acceptable levels. ADVANCES IN 
      KNOWLEDGE: Inter- and intrafractional changes did not affect carbon-ion beam 
      prostate treatment accuracy.
FAU - Mori, S
AU  - Mori S
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Inaniwa, T
AU  - Inaniwa T
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Miki, K
AU  - Miki K
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Tanimoto, K
AU  - Tanimoto K
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Tajiri, M
AU  - Tajiri M
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Kuroiwa, D
AU  - Kuroiwa D
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Nakao, M
AU  - Nakao M
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Shiraishi, Y
AU  - Shiraishi Y
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Shibayama, K
AU  - Shibayama K
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
FAU - Tsuji, H
AU  - Tsuji H
AD  - Research Center for Charged Particle Therapy, National Institute of Radiological 
      Sciences, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150507
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Heavy Ion Radiotherapy/*methods
MH  - Humans
MH  - Male
MH  - *Patient Positioning
MH  - Prostatic Neoplasms/diagnostic imaging/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Tomography, X-Ray Computed
PMC - PMC4628517
EDAT- 2015/05/08 06:00
MHDA- 2015/10/30 06:00
PMCR- 2016/07/01
CRDT- 2015/05/08 06:00
PHST- 2015/05/08 06:00 [entrez]
PHST- 2015/05/08 06:00 [pubmed]
PHST- 2015/10/30 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - 10.1259/bjr.20140623 [doi]
PST - ppublish
SO  - Br J Radiol. 2015 Jul;88(1051):20140623. doi: 10.1259/bjr.20140623. Epub 2015 May 
      7.