PMID- 25951923
OWN - NLM
STAT- MEDLINE
DCOM- 20170201
LR  - 20220330
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Linking)
VI  - 29
IP  - 7
DP  - 2016 Oct
TI  - Factors associated with nonresponse to proton pump inhibitors therapy in patients 
      referred for esophageal pH-impedance monitoring.
PG  - 787-793
LID - 10.1111/dote.12374 [doi]
AB  - Nonresponse to proton pump inhibitors (PPI) concerns up to 40% of patients 
      treated for gastroesophageal reflux disease (GERD). Identifying predictive 
      factors of nonresponse might help to optimize patients' treatment. The aim of 
      this study was to determine clinical factors associated with nonresponse to PPI 
      therapy in patients referred for pH-impedance monitoring. One hundred and 
      sixty-eight consecutive patients (105 females, mean age 52 years, range 17-83) 
      were included between October 2011 and May 2013. Before the realization of 
      high-resolution manometry and 24-hour pH-impedance monitoring they completed a 
      questionnaire including Rome III criteria for functional dyspepsia and irritable 
      bowel syndrome (IBS). Comparisons between patients with and without PPI response 
      were performed using chi-square or analysis of variance tests. One hundred and 
      twenty-six patients (83%) were considered as PPI nonresponders and 26 (17%) as 
      responders. No significant difference was observed for age and body mass index. 
      No manometric and pH-impedance profiles were identified as associated with PPI 
      response. The percentage of patients with functional dyspepsia and IBS was higher 
      in PPI nonresponders patients than in responders (65.6% and 27.2%, respectively, 
      vs. 38.5% and 7.7%, P = 0.01 and P = 0.03). This study confirms that functional 
      digestive disorders are more frequent in patients with persistent GERD symptoms 
      on PPI and they might be indicative of nonresponse to PPI therapy.
CI  - (c) 2015 International Society for Diseases of the Esophagus.
FAU - Garros, A
AU  - Garros A
AD  - Hospices Civils de Lyon, Digestive Physiology, Edouard Herriot Hospital, Lyon, 
      France.
FAU - Mion, F
AU  - Mion F
AD  - Hospices Civils de Lyon, Digestive Physiology, Edouard Herriot Hospital, Lyon, 
      France.
AD  - Lyon I University, Lyon, France.
AD  - LabTAU, Lyon, France.
FAU - Marjoux, S
AU  - Marjoux S
AD  - Hospices Civils de Lyon, Digestive Physiology, Edouard Herriot Hospital, Lyon, 
      France.
FAU - Damon, H
AU  - Damon H
AD  - Hospices Civils de Lyon, Digestive Physiology, Edouard Herriot Hospital, Lyon, 
      France.
FAU - Roman, S
AU  - Roman S
AD  - Hospices Civils de Lyon, Digestive Physiology, Edouard Herriot Hospital, Lyon, 
      France. roman.sabine@gmail.com.
AD  - Lyon I University, Lyon, France. roman.sabine@gmail.com.
AD  - LabTAU, Lyon, France. roman.sabine@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150508
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - *Drug Resistance
MH  - Dyspepsia/complications
MH  - *Esophageal pH Monitoring
MH  - Esophagus/*drug effects/physiopathology
MH  - Female
MH  - Gastroesophageal Reflux/complications/*drug therapy/physiopathology
MH  - Humans
MH  - Irritable Bowel Syndrome/complications
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*pharmacology
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - PPI response
OT  - dyspepsia
OT  - gastroesophageal reflux disease
OT  - irritable bowel syndrome
OT  - pH-impedance monitoring
EDAT- 2015/05/09 06:00
MHDA- 2017/02/02 06:00
CRDT- 2015/05/09 06:00
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2017/02/02 06:00 [medline]
PHST- 2015/05/09 06:00 [entrez]
AID - 10.1111/dote.12374 [doi]
PST - ppublish
SO  - Dis Esophagus. 2016 Oct;29(7):787-793. doi: 10.1111/dote.12374. Epub 2015 May 8.