PMID- 25952713
OWN - NLM
STAT- MEDLINE
DCOM- 20160209
LR  - 20220310
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 25
IP  - 6
DP  - 2015 Nov-Dec
TI  - Normative data for macular volume with high-definition spectral-domain optical 
      coherence tomography (Spectralis).
PG  - 546-51
LID - 10.5301/ejo.5000582 [doi]
AB  - PURPOSE: To establish normative data for macular volume by spectral-domain 
      optical coherence tomography (SD-OCT) in subjects with no known retinal disease. 
      METHODS: In an academic institutional setting, 50 subjects (age range 20-84 
      years) with no known retinal disease, best-corrected visual acuity 20/20, and 
      normal intraocular pressure were enrolled. The subjects were divided into 3 age 
      groups: group 1 included subjects 20-40 years of age, group 2 included subjects 
      41-60 years of age, and group 3 included subjects 61 years of age and older. All 
      subjects underwent a complete ophthalmologic examination and testing, if needed, 
      to rule out any retinal diseases or glaucoma. Retinal volume (RV) in 9 Early 
      Treatment Diabetic Retinopathy Study (ETDRS) subfields and total macular volume 
      (TMV) inclusive of all 9 subfields were analyzed. Statistical analyses were 
      carried out using analysis of variance. RESULTS: Overall, the mean TMV +/- SD for 
      ETDRS circles with a diameter of 1, 2.22, and 3.45 mm was determined to be 3.04 +/- 
      0.14 mm3. Among the ETDRS subfields, RV was highest in the nasal outer field, 
      with a mean of 0.47 +/- 0.02 mm3. The TMV did not show a significant difference 
      with age (p = 0.17). However, TMV was significantly higher in males (p = 0.003) 
      and in Caucasian and Asian subjects compared to African Americans (p = 0.017). 
      CONCLUSIONS: Normative values for total macular volume in ETDRS subfields in 
      otherwise healthy eyes were measured to be 3.04 +/- 0.14 mm3.
FAU - Murthy, Ravi K
AU  - Murthy RK
AD  - Department of Ophthalmology, College of Medicine, University of Florida, 
      Jacksonville, FL - USA.
FAU - Diaz, Michelle
AU  - Diaz M
AD  - Department of Ophthalmology, College of Medicine, University of Florida, 
      Jacksonville, FL - USA.
FAU - Chalam, Kakarla V
AU  - Chalam KV
AD  - Department of Ophthalmology, College of Medicine, University of Florida, 
      Jacksonville, FL - USA.
FAU - Grover, Sandeep
AU  - Grover S
AD  - Department of Ophthalmology, College of Medicine, University of Florida, 
      Jacksonville, FL - USA.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150429
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
CIN - Eur J Ophthalmol. 2016 Mar-Apr;26(2):e36. PMID: 26659021
CIN - Eur J Ophthalmol. 2016 Mar-Apr;26(2):e35. PMID: 26692066
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reference Values
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2015/05/09 06:00
MHDA- 2016/02/10 06:00
CRDT- 2015/05/09 06:00
PHST- 2015/01/29 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2016/02/10 06:00 [medline]
AID - C1546DD4-0A07-4542-9EAA-67BAF0B52982 [pii]
AID - 10.5301/ejo.5000582 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2015 Nov-Dec;25(6):546-51. doi: 10.5301/ejo.5000582. Epub 2015 
      Apr 29.