PMID- 25952950
OWN - NLM
STAT- MEDLINE
DCOM- 20160121
LR  - 20220409
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 29
IP  - 7
DP  - 2015 Jul
TI  - Correlation of structure and function of the macula in patients with retinitis 
      pigmentosa.
PG  - 895-901
LID - 10.1038/eye.2015.61 [doi]
AB  - PURPOSE: To correlate the structure of the macula, as measured by spectral-domain 
      optical coherence tomography (SD-OCT) and function, as measured by microperimetry 
      (MAIA) in patients with retinitis pigmentosa (RP) and relatively good visual 
      acuity. DESIGN: Prospective, cross-sectional, non-intervention study. SUBJECTS: 
      Patients with RP. METHODS: Thirty patients with RP and good central visual acuity 
      were identified. Each patient underwent SD-OCT of the macula and microperimetry. 
      The images were overlaid using the custom-designed software. The retinal 
      sensitivity by microperimetry was correlated with corresponding retinal 
      thickness, as measured by the SD-OCT. ELM, COST, and IS/OS junction were scored 
      as intact, disrupted, or absent. MAIN OUTCOME MEASURES: Comparing the retinal 
      sensitivity on the MAIA with various measurements on the SD-OCT. RESULTS: The 
      retinal sensitivity on the MAIA showed a significant correlation with total 
      retinal thickness and outer retinal thickness on the SD-OCT. There was no 
      association with either the inner retinal thickness or the choroidal thickness. 
      ORT showed a statistically significant correlation with the anatomical 
      classification of ELM (r=-0.76, P<0.001), IS/OS (r=-0.800, P<0.001), and COST 
      (r=-0.733, P<0.001). CONCLUSION: This study determined that there was a high 
      correlation of the structure and function of the central macula in patients with 
      RP. These studies are important to establish surrogate markers that can be used 
      as end points for various tests in future therapeutic clinical trials.
FAU - Battu, R
AU  - Battu R
AD  - Department of Vitreoretina, Narayana Nethralaya, Bangalore, India.
FAU - Khanna, A
AU  - Khanna A
AD  - Department of Vitreoretina, Narayana Nethralaya, Bangalore, India.
FAU - Hegde, B
AU  - Hegde B
AD  - Forus Health Pvt. Ltd, Bangalore, India.
FAU - Berendschot, T T J M
AU  - Berendschot TT
AD  - University Maastricht, Maastricht, The Netherlands.
FAU - Grover, S
AU  - Grover S
AD  - University of Florida, Jacksonville, FL, USA.
FAU - Schouten, J S A G
AU  - Schouten JS
AD  - University Maastricht, Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20150508
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinitis Pigmentosa/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
MH  - Young Adult
PMC - PMC4506342
EDAT- 2015/05/09 06:00
MHDA- 2016/01/23 06:00
PMCR- 2016/07/01
CRDT- 2015/05/09 06:00
PHST- 2014/09/30 00:00 [received]
PHST- 2015/03/04 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2016/01/23 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - eye201561 [pii]
AID - 10.1038/eye.2015.61 [doi]
PST - ppublish
SO  - Eye (Lond). 2015 Jul;29(7):895-901. doi: 10.1038/eye.2015.61. Epub 2015 May 8.