PMID- 25953150
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20221207
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 36
IP  - 7
DP  - 2015 Jul
TI  - The HLA-B*4601-DRB1*0901 haplotype is positively correlated with juvenile ocular 
      myasthenia gravis in a southern Chinese Han population.
PG  - 1135-40
LID - 10.1007/s10072-015-2235-9 [doi]
AB  - Myasthenia gravis (MG) is a sporadic disorder that has been increasingly linked 
      to inherited genetic factors. Previous studies have demonstrated that human 
      leukocyte antigen (HLA) plays an important role in the pathogenesis of MG. We 
      determined the genotypes of the HLA-A, B, and DRB1 alleles in 257 southern 
      Chinese Han MG patients using polymerase chain reaction sequence-based typing 
      (PCR-SBT). The allele frequencies in the MG patients were compared to 292 healthy 
      controls using the case-control method. HLA-A*0207, HLA-B*4601, HLA-DRB1*0403, 
      HLA-DRB1*0901, and HLA-DRB1*1602 were more frequent in juvenile ocular MG 
      patients than controls. HLA-DRB1*0701 was significantly reduced in the juvenile 
      ocular MG group compared with controls. HLA-A*0207-B*4601, HLA-B*4601-DRB1*0403, 
      HLA-B*4601-DRB1*0901, and HLA-B*4601-DRB1*1602 were found to be in strong linkage 
      disequilibrium in juvenile ocular MG patients. Within the MG patients, there was 
      a strong positive association between HLA-B*4601-DRB1*0901 and juvenile ocular MG 
      patients, and the value of odds ratios (OR) decreased as the disease became more 
      severe and the age of onset increased. We believe this could be the main heredity 
      phenotype in juvenile ocular MG patients from southern China and may be a 
      clinical marker to predict the severity of the disease.
FAU - Feng, Hui-Yu
AU  - Feng HY
AD  - Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 
      58 Zhongshan 2nd Road, Guangzhou, 510080, China.
FAU - Yang, Li-Xuan
AU  - Yang LX
FAU - Liu, Wei-Bin
AU  - Liu WB
FAU - Huang, Xin
AU  - Huang X
FAU - Qiu, Li
AU  - Qiu L
FAU - Li, Yan
AU  - Li Y
LA  - eng
PT  - Journal Article
DEP - 20150508
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*46:01 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Asian People/ethnology/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Myasthenia Gravis/epidemiology/ethnology/*genetics
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2015/05/09 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/05/09 06:00
PHST- 2014/11/04 00:00 [received]
PHST- 2015/04/28 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 10.1007/s10072-015-2235-9 [doi]
PST - ppublish
SO  - Neurol Sci. 2015 Jul;36(7):1135-40. doi: 10.1007/s10072-015-2235-9. Epub 2015 May 
      8.