PMID- 25953480
OWN - NLM
STAT- MEDLINE
DCOM- 20160808
LR  - 20161020
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 35
IP  - 8
DP  - 2015 Nov
TI  - 5-year study of a polyacrylamide hydrogel-based filler for rehabilitation of 
      HIV-related facial lipoatrophy.
PG  - 1021-9
LID - 10.1093/asj/sjv036 [doi]
AB  - BACKGROUND: Lipoatrophy of the face negatively impacts the quality of life and 
      body image of individuals on antiretroviral therapy. Facial fillers can minimize 
      the stigma associated with the human immonodeficiency virus (HIV). OBJECTIVES: In 
      this 5-year follow-up study, the author assessed the safety and efficacy of a 
      permanent, non-biodegradable, polyacrylamide hydrogel for facial volume 
      restoration, and compared the results with those of a previous 18-month follow-up 
      study. METHODS: Thirty-one HIV-positive individuals, initially enrolled in the 
      study between January 2008 and January 2009, received treatment of facial wasting 
      by injection of the polyacrylamide gel until complete volume restoration was 
      achieved. Asepsis rules were strictly observed before and during each injection 
      session. Patients evaluated their aesthetic outcomes on a visual analog scale. 
      RESULTS: Patient satisfaction was high. There was no occurrence of local 
      infection, foreign-body reaction, or product during the 5 years of follow-up. 
      Small, palpable, nonvisible nodules were recorded in nine cases. It appears that 
      these same nodules were present in the 18-month study. It is believed that the 
      nodules were caused by overfilling in the same site. CONCLUSIONS: As supported by 
      the initial 18-month study, polyacrylamide hydrogel filler appears safe and 
      effective for the treatment of HIV-related lipoatrophy. With strict observation 
      of asepsis rules and patient adherence to posttreatment instructions, this filler 
      can be ideal for treating facial wasting in patients with HIV. LEVEL OF EVIDENCE: 
      3 Therapeutic.
CI  - (c) 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and 
      permission: journals.permissions@oup.com.
FAU - Rauso, Raffaele
AU  - Rauso R
AD  - Dr Rauso is an Assistant Professor in the Department of Dentistry at the 
      University of Foggia, Foggia, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150507
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
RN  - 0 (Acrylic Resins)
RN  - 0 (Antiviral Agents)
RN  - 0 (polyacrylamide gels)
SB  - IM
MH  - Acrylic Resins/adverse effects/*therapeutic use
MH  - Adult
MH  - Ambulatory Care/methods
MH  - Antiviral Agents/*adverse effects/therapeutic use
MH  - Cosmetic Techniques
MH  - Esthetics
MH  - Face
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*complications/diagnosis/drug therapy
MH  - HIV-Associated Lipodystrophy Syndrome/etiology/psychology/*rehabilitation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2015/05/09 06:00
MHDA- 2016/08/09 06:00
CRDT- 2015/05/09 06:00
PHST- 2015/02/02 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2016/08/09 06:00 [medline]
AID - sjv036 [pii]
AID - 10.1093/asj/sjv036 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2015 Nov;35(8):1021-9. doi: 10.1093/asj/sjv036. Epub 2015 May 7.