PMID- 25954081
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150508
LR  - 20201001
IS  - 0976-7428 (Print)
IS  - 0976-1799 (Electronic)
IS  - 0976-1799 (Linking)
VI  - 7
IP  - 4
DP  - 2015 Apr
TI  - Treatment guidelines and prognosis of immune reconstitution inflammatory syndrome 
      patients: a review.
PG  - 92-5
AB  - Immune reconstitution inflammatory syndrome (IRIS) is an "unmasking" or 
      paradoxical worsening of a pre-existing infection after commencement of highly 
      active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV) - 
      infected patients. The use of HAART in the management of HIV patients restores 
      immune responses against pathogens however in few patients, the reconstituted 
      immune system leads to IRIS. As the treatment protocols are not standardized for 
      IRIS, this leads to short-term morbidity or in some cases also mortality. 
      Therefore, treatment in these patients is a huge challenge and further more 
      research regarding the immunopathogenesis, diagnosis and management of IRIS 
      should be well thought-out. To understand the immunopathogenesis of IRIS it will 
      be difficult to elucidate the intrinsic dynamics of immune cells after initiation 
      of HAART but, there are few biomarkers which help to predict or diagnose IRIS and 
      develop specific treatment, following initiation of HIV therapy. This review is 
      an attempt to put light on those patients with IRIS with treatment guidelines for 
      the management of the progression of it.
FAU - Murthy, Anup R
AU  - Murthy AR
AD  - Reader, Department of Orthodontics, Mathrusri Ramabai Ambedkar Dental College and 
      Hospital, Bengaluru, Karnataka, India.
FAU - Marulappa, Rekha
AU  - Marulappa R
AD  - Post-graduate, Department of Oral Pathology and Microbiology, JSS Dental College 
      and Hospital, Mysore, Karnataka, India.
FAU - Hegde, Usha
AU  - Hegde U
AD  - Professor and Head, Department of Oral Pathology and Microbiology, JSS Dental 
      College and Hospital, Mysore, Karnataka, India.
FAU - Kappadi, Damodhar
AU  - Kappadi D
AD  - Reader, Department of Pedodontics, NIMS Dental College, Jaipur, Rajasthan, India.
FAU - Ambikathanaya, U K
AU  - Ambikathanaya UK
AD  - Senior Lecturer, Department of Conservative Dentistry and Endodontics, JSS Dental 
      College and Hospital, Mysore, Karnataka, India.
FAU - Nair, Priyanka
AU  - Nair P
AD  - Post-graduate, Department of Oral Pathology and Microbiology, JSS Dental College 
      and Hospital, Mysore, Karnataka, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Int Oral Health
JT  - Journal of international oral health : JIOH
JID - 101562691
PMC - PMC4409807
OTO - NOTNLM
OT  - CD4 cell count
OT  - highly active antiretroviral therapy
OT  - human immunodeficiency virus
OT  - immune reconstitution inflammatory syndrome
OT  - management
COIS- Conflicts of Interest: None
EDAT- 2015/05/09 06:00
MHDA- 2015/05/09 06:01
PMCR- 2015/06/01
CRDT- 2015/05/09 06:00
PHST- 2014/11/20 00:00 [received]
PHST- 2015/02/15 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2015/05/09 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - JIOH-7-92 [pii]
PST - ppublish
SO  - J Int Oral Health. 2015 Apr;7(4):92-5.