PMID- 25956003
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20240520
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 123
IP  - 10
DP  - 2015 Oct
TI  - Brominated Flame Retardants and Other Persistent Organohalogenated Compounds in 
      Relation to Timing of Puberty in a Longitudinal Study of Girls.
PG  - 1046-52
LID - 10.1289/ehp.1408778 [doi]
AB  - BACKGROUND: Exposure to hormonally active chemicals could plausibly affect 
      pubertal timing, so we are investigating this in the Breast Cancer and the 
      Environment Research Program. OBJECTIVES: Our goal was to examine persistent 
      organic pollutants (POPs) in relation to pubertal onset. METHODS: Ethnically 
      diverse cohorts of 6- to 8-year-old girls (n = 645) provided serum for measure of 
      polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), 
      organochlorine pesticides (OCPs), and lipids. Tanner stages [breast (B) and pubic 
      hair (PH)], and body mass index (BMI) were measured at up to seven annual clinic 
      visits. Using accelerated failure time models, we calculated time ratios (TRs) 
      for age at Tanner stages 2 or higher (2+) and POPs quartiles (Q1-4), adjusting 
      for confounders (race/ethnicity, site, caregiver education, and income). We also 
      calculated prevalence ratios (PRs) of Tanner stages 2+ at time of blood sampling. 
      RESULTS: Cross-sectionally, the prevalence of B2+ and PH2+ was inversely related 
      to chemical serum concentrations; but after adjustment for confounders, only the 
      associations with B2+, not PH2+, were statistically significant. Longitudinally, 
      the age at pubertal transition was consistently older with greater chemical 
      concentrations; for example: adjusted TR for B2+ and Q4 for SigmaPBDE = 1.05; 95% CI: 
      1.02, 1.08, for SigmaPCB = 1.05; 95% CI: 1.01, 1.08, and for SigmaOCP = 1.10; 95% CI: 
      1.06, 1.14, indicating median ages of about 6 and 11 months older than least 
      exposed, and with similar effect estimates for PH2+. Adjusting for BMI attenuated 
      associations for PCBs and OCPs but not for PBDEs. CONCLUSIONS: This first 
      longitudinal study of puberty in girls with serum POPs measurements (to our 
      knowledge) reveals a delay in onset with higher concentrations.
FAU - Windham, Gayle C
AU  - Windham GC
AD  - California Department of Public Health, Richmond, California, USA.
FAU - Pinney, Susan M
AU  - Pinney SM
FAU - Voss, Robert W
AU  - Voss RW
FAU - Sjodin, Andreas
AU  - Sjodin A
FAU - Biro, Frank M
AU  - Biro FM
FAU - Greenspan, Louise C
AU  - Greenspan LC
FAU - Stewart, Susan
AU  - Stewart S
FAU - Hiatt, Robert A
AU  - Hiatt RA
FAU - Kushi, Lawrence H
AU  - Kushi LH
LA  - eng
GR  - U01 ES012770/ES/NIEHS NIH HHS/United States
GR  - U01 ES12770/ES/NIEHS NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - P30 ES006096/ES/NIEHS NIH HHS/United States
GR  - P30-ES006096/ES/NIEHS NIH HHS/United States
GR  - U01 ES012801/ES/NIEHS NIH HHS/United States
GR  - U01ES012801/ES/NIEHS NIH HHS/United States
GR  - U01 ES019435/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150508
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
CIN - Environ Health Perspect. 2015 Oct;123(10):A266. PMID: 26421753
MH  - Breast/drug effects/growth & development
MH  - California
MH  - Child
MH  - Endocrine Disruptors/blood
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Flame Retardants/analysis
MH  - Hair/drug effects/growth & development
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Longitudinal Studies
MH  - Ohio
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Puberty/*drug effects
PMC - PMC4590751
COIS- The contents of this report are solely the responsibility of the authors and do 
      not necessarily represent the official views of the NIEHS, the NCI, the Centers 
      for Diseases Control and Prevention, or the CDPH. G.C.W. is employed by 
      EHIB/CDPH; R.W.V. was employed by Impact Assessment Inc., at the time the work 
      was completed; L.C.G. is employed by Kaiser Permanente Medical Care Program; and 
      L.H.K. is employed by the Division of Research, Kaiser Permanente. The authors 
      declare they have no actual or potential competing financial interests.
EDAT- 2015/05/09 06:00
MHDA- 2016/07/14 06:00
PMCR- 2015/10/01
CRDT- 2015/05/09 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2015/05/06 00:00 [accepted]
PHST- 2015/05/09 06:00 [entrez]
PHST- 2015/05/09 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - ehp.1408778 [pii]
AID - 10.1289/ehp.1408778 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2015 Oct;123(10):1046-52. doi: 10.1289/ehp.1408778. Epub 
      2015 May 8.