PMID- 25956629
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20201220
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 165
IP  - 2-3
DP  - 2015 Jul
TI  - Auditory P300 as a predictor of short-term prognosis in subjects at clinical high 
      risk for psychosis.
PG  - 138-44
LID - S0920-9964(15)00228-5 [pii]
LID - 10.1016/j.schres.2015.04.033 [doi]
AB  - BACKGROUND: The aim of this study was to investigate whether P300 could predict 
      the short-term prognosis of subjects at clinical high risk (CHR) for psychosis 
      who do not convert to psychotic disorder (non-converters). METHOD: CHR subjects 
      were examined with auditory P300 at baseline, and their clinical state was 
      regularly assessed up to 2 years. 45 CHR non-converters were divided into 
      remitter and non-remitter groups. Repeated-measures analysis of variance (ANOVA) 
      was performed to compare baseline P300 between the two groups. Multiple 
      regression analysis was used to identify factors predicting symptomatic or 
      functional improvement in CHR subjects during the follow-up period. RESULTS: 
      There were no group differences in P300 amplitude or latency between CHR 
      remitters and non-remitters. In the multiple regression analysis, P300 amplitude 
      at Pz (beta=0.206, 95% confidence interval [95CI]=0.035 to 0.567, p=0.028) 
      significantly predicted later amelioration of the Scale of Prodromal Symptoms 
      (SOPS) negative symptoms. Improvement in SOPS general symptoms was significantly 
      predicted by P300 amplitude at Pz (beta=0.255, 95CI=0.065 to 0.455, p=0.010) and 
      mood stabilizer use (beta=0.199, 95CI=0.081 to 4.154, p=0.042). CONCLUSIONS: These 
      results indicate that P300 may be a possible predictor of improvement in negative 
      and general symptoms in CHR non-converters. Our findings support the 
      recommendation that a broader concept of assessment guidelines is needed to 
      forecast clinical outcome and provide appropriate interventions for CHR 
      non-converters.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Kim, Minah
AU  - Kim M
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Institute of Human Behavioral Sciences, Seoul National University-Medical 
      Research Center, Seoul, Republic of Korea.
FAU - Lee, Suji
AU  - Lee S
AD  - Department of Brain and Cognitive Science, Seoul National University College of 
      Natural Science, Seoul, Republic of Korea.
FAU - Kim, Sung Nyun
AU  - Kim SN
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Institute of Human Behavioral Sciences, Seoul National 
      University-Medical Research Center, Seoul, Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Institute of Human Behavioral Sciences, Seoul National 
      University-Medical Research Center, Seoul, Republic of Korea; Department of Brain 
      and Cognitive Science, Seoul National University College of Natural Science, 
      Seoul, Republic of Korea. Electronic address: kwonjs@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150505
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Acoustic Stimulation
MH  - Adolescent
MH  - Analysis of Variance
MH  - Electroencephalography
MH  - Event-Related Potentials, P300/*physiology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Predictive Value of Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/*physiopathology
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Clinical high risk for psychosis
OT  - Event-related potential
OT  - P300
OT  - Prognosis
OT  - Schizophrenia
EDAT- 2015/05/10 06:00
MHDA- 2016/02/24 06:00
CRDT- 2015/05/10 06:00
PHST- 2014/11/19 00:00 [received]
PHST- 2015/03/30 00:00 [revised]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/05/10 06:00 [entrez]
PHST- 2015/05/10 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
AID - S0920-9964(15)00228-5 [pii]
AID - 10.1016/j.schres.2015.04.033 [doi]
PST - ppublish
SO  - Schizophr Res. 2015 Jul;165(2-3):138-44. doi: 10.1016/j.schres.2015.04.033. Epub 
      2015 May 5.