PMID- 25957017
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20220318
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 232
IP  - 3
DP  - 2015 Jun 30
TI  - Dissociated large-scale functional connectivity networks of the precuneus in 
      medication-naive first-episode depression.
PG  - 250-6
LID - S0925-4927(15)00063-3 [pii]
LID - 10.1016/j.pscychresns.2015.03.003 [doi]
AB  - An imbalance in neural activity within large-scale networks appears to be an 
      important pathophysiological aspect of depression. Yet, there is little consensus 
      regarding the abnormality within the default mode network (DMN) in major 
      depressive disorder (MDD). In the present study, 16 first-episode, 
      medication-naive patients with MDD and 16 matched healthy controls underwent 
      functional magnetic resonance imaging (fMRI) at rest. With the precuneus (a 
      central node of the DMN) as a seed region, functional connectivity (FC) was 
      measured across the entire brain. The association between the FC of the precuneus 
      and overall symptom severity was assessed using the Hamilton Depression Rating 
      Scale. Patients with MDD exhibited a more negative relationship between the 
      precuneus and the non-DMN regions, including the sensory processing regions 
      (fusiform gyrus, postcentral gyrus) and the secondary motor cortex (supplementary 
      motor area and precentral gyrus). Moreover, greater severity of depression was 
      associated with greater anti-correlation between the precuneus and the 
      temporo-parietal junction as well as stronger positive connectivity between the 
      precuneus and the dorsomedial prefrontal cortex. These results indicate that 
      dissociated large-scale networks of the precuneus may contribute to the clinical 
      expression of depression in MDD.
CI  - Copyright (c) 2015. Published by Elsevier Ireland Ltd.
FAU - Peng, Daihui
AU  - Peng D
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200030, China.
FAU - Liddle, Elizabeth B
AU  - Liddle EB
AD  - Division of Psychiatry and Applied Psychology, School of Medicine, University of 
      Nottingham, Nottingham NG7 2TU, UK; Center for Translational Neuroimaging, 
      Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, Nottingham NG7 
      2TU, UK.
FAU - Iwabuchi, Sarina J
AU  - Iwabuchi SJ
AD  - Division of Psychiatry and Applied Psychology, School of Medicine, University of 
      Nottingham, Nottingham NG7 2TU, UK; Center for Translational Neuroimaging, 
      Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, Nottingham NG7 
      2TU, UK.
FAU - Zhang, Chen
AU  - Zhang C
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200030, China; Key Laboratory of Animal 
      Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan 
      Province, Kunming Institute of Zoology, Kunming 650223, China.
FAU - Wu, Zhiguo
AU  - Wu Z
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200030, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Huashan Hospital, Shanghai Medical College of Fudan University, Fudan University, 
      Shanghai 200032, China.
FAU - Jiang, Kaida
AU  - Jiang K
AD  - Huashan Hospital, Shanghai Medical College of Fudan University, Fudan University, 
      Shanghai 200032, China.
FAU - Xu, Lin
AU  - Xu L
AD  - Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese 
      Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 
      650223, China.
FAU - Liddle, Peter F
AU  - Liddle PF
AD  - Division of Psychiatry and Applied Psychology, School of Medicine, University of 
      Nottingham, Nottingham NG7 2TU, UK; Center for Translational Neuroimaging, 
      Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, Nottingham NG7 
      2TU, UK.
FAU - Palaniyappan, Lena
AU  - Palaniyappan L
AD  - Division of Psychiatry and Applied Psychology, School of Medicine, University of 
      Nottingham, Nottingham NG7 2TU, UK; Center for Translational Neuroimaging, 
      Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, Nottingham NG7 
      2TU, UK. Electronic address: Lena.Palaniyappan@nottingham.ac.uk.
FAU - Fang, Yiru
AU  - Fang Y
AD  - Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200030, China. Electronic address: 
      yirufang@gmail.com.
LA  - eng
GR  - WT096002/z/11/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150320
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Depressive Disorder, Major/diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Parietal Lobe/*physiopathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Depression
OT  - Functional connectivity network
OT  - Functional magnetic resonance imaging
OT  - Precuneus
OT  - Resting state
EDAT- 2015/05/10 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/05/10 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/12/04 00:00 [revised]
PHST- 2015/03/11 00:00 [accepted]
PHST- 2015/05/10 06:00 [entrez]
PHST- 2015/05/10 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0925-4927(15)00063-3 [pii]
AID - 10.1016/j.pscychresns.2015.03.003 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Jun 30;232(3):250-6. doi: 10.1016/j.pscychresns.2015.03.003. 
      Epub 2015 Mar 20.