PMID- 25957087
OWN - NLM
STAT- MEDLINE
DCOM- 20160323
LR  - 20150606
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 411
DP  - 2015 Aug 15
TI  - 9-Demethoxy-medicarpin promotes peak bone mass achievement and has bone 
      conserving effect in ovariectomized mice: Positively regulates osteoblast 
      functions and suppresses osteoclastogenesis.
PG  - 155-66
LID - S0303-7207(15)00224-5 [pii]
LID - 10.1016/j.mce.2015.04.023 [doi]
AB  - We report a new bone anabolic and anti-catabolic pterocarpan 
      9-demethoxy-medicarpin (DMM) for the management of postmenopausal osteoporosis. 
      DMM promoted osteoblast functions via activation of P38MAPK/BMP-2 pathway and 
      suppressed osteoclastogenesis in bone marrow cells (BMCs). In calvarial 
      osteoblasts, DMM blocked nuclear factor kappaB (NFkappaB) signaling and inhibited the 
      mRNA levels of pro-inflammatory cytokines. DMM treatment led to increased OPG 
      (osteoprotegrin) and decreased transcript levels of TRAP (tartarate resistant 
      acid phosphatase), RANK (receptor activator of NFkappaB) and RANKL (RANK ligand) in 
      osteoblast-osteoclast co-cultures. Immature female SD rats administered with DMM 
      exhibited increased bone mineral density, bone biomechanical strength, new bone 
      formation and cortical bone parameters. Ovx mice administered with DMM led to 
      significant restoration of trabecular microarchitecture and had reduced formation 
      of osteoclasts and increased formation of osteoprogenitor cells in BMCs. DMM 
      exhibited no uterine estrogenicity. Overall, these results demonstrate the 
      therapeutic potential of DMM for the management of postmenopausal osteoporosis.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Goel, Atul
AU  - Goel A
AD  - Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 
      226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 
      110001, India. Electronic address: atul_goel@cdri.res.in.
FAU - Raghuvanshi, Ashutosh
AU  - Raghuvanshi A
AD  - Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 
      226031, India.
FAU - Kumar, Amit
AU  - Kumar A
AD  - Medicinal & Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 
      226031, India.
FAU - Gautam, Abnish
AU  - Gautam A
AD  - Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, 
      India.
FAU - Srivastava, Kamini
AU  - Srivastava K
AD  - Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, 
      India.
FAU - Kureel, Jyoti
AU  - Kureel J
AD  - Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, 
      India.
FAU - Singh, Divya
AU  - Singh D
AD  - Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow 226031, 
      India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150505
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Pterocarpans)
RN  - 6TX086I6IG (medicarpin)
SB  - IM
MH  - Animals
MH  - Bone Density/*drug effects
MH  - Bone Density Conservation Agents/*pharmacology/therapeutic use
MH  - Cell Differentiation/drug effects
MH  - Female
MH  - Humans
MH  - Mice
MH  - Osteoblasts/cytology/*drug effects
MH  - Osteoclasts/cytology/*drug effects
MH  - Osteoporosis, Postmenopausal/drug therapy
MH  - Ovariectomy
MH  - Pterocarpans/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Bone-anabolics
OT  - Bone-anticatabolics
OT  - Demethoxy-medicarpin
OT  - Osteoporosis
OT  - Pterocarpans
EDAT- 2015/05/10 06:00
MHDA- 2016/03/24 06:00
CRDT- 2015/05/10 06:00
PHST- 2015/01/01 00:00 [received]
PHST- 2015/04/11 00:00 [revised]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/05/10 06:00 [entrez]
PHST- 2015/05/10 06:00 [pubmed]
PHST- 2016/03/24 06:00 [medline]
AID - S0303-7207(15)00224-5 [pii]
AID - 10.1016/j.mce.2015.04.023 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2015 Aug 15;411:155-66. doi: 10.1016/j.mce.2015.04.023. Epub 
      2015 May 5.