PMID- 25957954
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20150606
IS  - 1872-8308 (Electronic)
IS  - 0376-6357 (Linking)
VI  - 116
DP  - 2015 Jul
TI  - Marble-burying is enhanced in 3xTg-AD mice, can be reversed by risperidone and it 
      is modulable by handling.
PG  - 69-74
LID - S0376-6357(15)00124-2 [pii]
LID - 10.1016/j.beproc.2015.05.001 [doi]
AB  - Translational research on behavioural and psychological symptoms of dementia 
      (BPSD) is relevant to the study the neuropsychiatric symptoms that strongly 
      affect the quality of life of the human Alzheimer's disease (AD) patient and 
      caregivers, frequently leading to early institutionalization. Among the 
      ethological behavioural tests for rodents, marble burying is considered to model 
      the spectrum of anxiety, psychotic and obsessive-compulsive like symptoms. The 
      present work was aimed to study the behavioural interactions of 12 month-old male 
      3xTg-AD mice with small objects using the marble-burying test, as compared to the 
      response elicited in age-matched non-transgenic (NTg) mice. The distinction of 
      the classical 'number of buried marbles' but also those left 'intact' and those 
      'changed' of position of marbles or partially buried (the transitional level of 
      interaction) provided new insights into the modelling of BPSD-like alterations in 
      this AD model. The analysis revealed genotype differences in the behavioural 
      patterns and predominant behaviors. In the NTg mice, predominance was shown in 
      the 'changed or partially buried', while interactions with marble were enhanced 
      in 3xTg-AD mice resulting in an increase of marble burying. Besides, 
      genotype-dependent meaningful correlations were found, with the marble test 
      pattern of 3xTg-AD mice being directly related to neophobia in the corner tests. 
      In both genotypes, the increase of burying was reversed by chronic treatment with 
      risperidone (1mg/kg, s.c.). In 3xTg-AD mice, the repetitive handling of animals 
      during the treatment also exerted modulatory effects. These distinct patterns 
      further characterize the modelling of BPSD-like symptoms in the 3xTg-AD mice, and 
      provide another behavioural tool to assess the benefits of preventive and/or 
      therapeutic strategies, as well as the potential action of risk factors for AD, 
      in this animal model.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Torres-Lista, Virginia
AU  - Torres-Lista V
AD  - Behavioral Neuroscience Group, Institute of Neuroscience, Universitat Autonoma de 
      Barcelona, Bellaterra, Spain; Department of Psychiatry and Forensic Medicine, 
      School of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain.
FAU - Lopez-Pousa, Secundino
AU  - Lopez-Pousa S
AD  - Research Unit and UVaMiD (Memory and Dementia Assessment Unit), Institut 
      d'Assistencia Sanitaria, Salt, Spain.
FAU - Gimenez-Llort, Lydia
AU  - Gimenez-Llort L
AD  - Behavioral Neuroscience Group, Institute of Neuroscience, Universitat Autonoma de 
      Barcelona, Bellaterra, Spain; Department of Psychiatry and Forensic Medicine, 
      School of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain. 
      Electronic address: lidia.gimenez@uab.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150506
PL  - Netherlands
TA  - Behav Processes
JT  - Behavioural processes
JID - 7703854
RN  - 0 (Antipsychotic Agents)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - *Alzheimer Disease
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Anxiety
MH  - Behavior, Animal/*drug effects/physiology
MH  - Disease Models, Animal
MH  - Exploratory Behavior/*drug effects/physiology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Activity/*drug effects/*physiology
MH  - Risperidone/*pharmacology
OTO - NOTNLM
OT  - Antipsychotics
OT  - Behavioural and psychological symptoms of dementia (BPSD)
OT  - Ethogram
OT  - Handling
OT  - Longitudinal study
OT  - QoL
OT  - Translational neuroscience
EDAT- 2015/05/11 06:00
MHDA- 2016/03/05 06:00
CRDT- 2015/05/11 06:00
PHST- 2014/07/15 00:00 [received]
PHST- 2015/05/01 00:00 [revised]
PHST- 2015/05/05 00:00 [accepted]
PHST- 2015/05/11 06:00 [entrez]
PHST- 2015/05/11 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
AID - S0376-6357(15)00124-2 [pii]
AID - 10.1016/j.beproc.2015.05.001 [doi]
PST - ppublish
SO  - Behav Processes. 2015 Jul;116:69-74. doi: 10.1016/j.beproc.2015.05.001. Epub 2015 
      May 6.