PMID- 25958869
OWN - NLM
STAT- MEDLINE
DCOM- 20160309
LR  - 20150511
IS  - 1348-2246 (Electronic)
IS  - 0910-6340 (Linking)
VI  - 31
IP  - 5
DP  - 2015
TI  - Fabrication of Fe3O4 Nanoparticle-coalesced Hydroxylated Multi-walled Carbon 
      Nanotubes for the Analysis of Strychnine in Human Serum.
PG  - 399-406
LID - 10.2116/analsci.31.399 [doi]
AB  - A magnetic carbon nanomaterial for Fe3O4-modified hydroxylated multi-walled 
      carbon nanotubes (Fe3O4-MWCNTs-OH) was prepared by the aggregating effect of 
      Fe3O4 nanoparticles on MWCNTs-OH, and this material was combined with 
      high-performance liquid chromatography (HPLC)/photodiode array detector (PAD) to 
      determine strychnine in human serum samples. Some important parameters that could 
      influence the extraction efficiency of strychnine were optimized, including the 
      extraction time, amounts of Fe3O4-MWCNTs-OH, pH of sample solution, desorption 
      solvent and desorption time. Under optimal conditions, the recoveries of spiked 
      serum samples were between 98.3 and 102.7%, and the relative standard deviations 
      (RSDs) ranged from 0.9 to 5.3%. The correlation coefficient was 0.9997. The LODs 
      and LOQs of strychnine were 6.2 and 20.5 ng mL(-1), at signal-to-noise ratios of 
      3 and 10, respectively. These experimental results showed that the proposed 
      method is feasible for the analysis of strychnine in serum samples.
FAU - Feng, Zufei
AU  - Feng Z
AD  - College of Forensic & Medicine, Xi'an Jiaotong University.
FAU - Xu, Yuehong
AU  - Xu Y
FAU - Wei, Shuguang
AU  - Wei S
FAU - Zhang, Bao
AU  - Zhang B
FAU - Guan, Fanglin
AU  - Guan F
FAU - Li, Shengbin
AU  - Li S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Anal Sci
JT  - Analytical sciences : the international journal of the Japan Society for 
      Analytical Chemistry
JID - 8511078
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Nanotubes, Carbon)
RN  - H9Y79VD43J (Strychnine)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Hydroxylation
MH  - Magnetite Nanoparticles/*chemistry
MH  - Molecular Structure
MH  - Nanotubes, Carbon/*chemistry
MH  - Strychnine/*blood/chemistry
EDAT- 2015/05/12 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/05/12 06:00
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - 10.2116/analsci.31.399 [doi]
PST - ppublish
SO  - Anal Sci. 2015;31(5):399-406. doi: 10.2116/analsci.31.399.