PMID- 25959732
OWN - NLM
STAT- MEDLINE
DCOM- 20150812
LR  - 20170912
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 86
IP  - 4
DP  - 2015 May 20
TI  - Theta Burst Firing Recruits BDNF Release and Signaling in Postsynaptic CA1 
      Neurons in Spike-Timing-Dependent LTP.
PG  - 1041-1054
LID - S0896-6273(15)00336-0 [pii]
LID - 10.1016/j.neuron.2015.04.007 [doi]
AB  - Timing-dependent LTP (t-LTP) is a physiologically relevant type of synaptic 
      plasticity that results from repeated sequential firing of action potentials 
      (APs) in pre- and postsynaptic neurons. t-LTP can be observed in vivo and is 
      proposed to be a cellular correlate of memory formation. While brain-derived 
      neurotrophic factor (BDNF) is essential to high-frequency stimulation-induced LTP 
      in many brain areas, the role of BDNF in t-LTP is largely unknown. Here, we 
      demonstrate a striking change in the expression mechanism of t-LTP in CA1 of the 
      hippocampus following two distinct modes of synaptic activation. Single 
      postsynaptic APs paired with presynaptic stimulation activated a BDNF-independent 
      canonical t-LTP. In contrast, a theta burst of postsynaptic APs preceded by 
      presynaptic stimulation elicited BDNF-dependent postsynaptic t-LTP that relied on 
      postsynaptic BDNF secretion. This suggests that BDNF release during burst-like 
      patterns of activity typically observed in vivo may play a crucial role during 
      memory formation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Edelmann, Elke
AU  - Edelmann E
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: 
      elke.edelmann@med.ovgu.de.
FAU - Cepeda-Prado, Efrain
AU  - Cepeda-Prado E
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Franck, Martin
AU  - Franck M
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Lichtenecker, Petra
AU  - Lichtenecker P
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Brigadski, Tanja
AU  - Brigadski T
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain 
      Sciences, Otto-von-Guericke University, Universitatsplatz 2, 39106 Magdeburg, 
      Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institut fur Physiologie, Otto-von-Guericke-Universitat, Medizinische Fakultat, 
      Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain 
      Sciences, Otto-von-Guericke University, Universitatsplatz 2, 39106 Magdeburg, 
      Germany. Electronic address: lessmann@med.ovgu.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150507
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CA1 Region, Hippocampal/*metabolism
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Memory/*physiology
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/physiology
MH  - Neurons/*physiology
MH  - Synaptic Potentials/physiology
MH  - Synaptic Transmission/physiology
EDAT- 2015/05/12 06:00
MHDA- 2015/08/13 06:00
CRDT- 2015/05/12 06:00
PHST- 2013/11/03 00:00 [received]
PHST- 2015/01/25 00:00 [revised]
PHST- 2015/03/31 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/08/13 06:00 [medline]
AID - S0896-6273(15)00336-0 [pii]
AID - 10.1016/j.neuron.2015.04.007 [doi]
PST - ppublish
SO  - Neuron. 2015 May 20;86(4):1041-1054. doi: 10.1016/j.neuron.2015.04.007. Epub 2015 
      May 7.