PMID- 25959789
OWN - NLM
STAT- MEDLINE
DCOM- 20160229
LR  - 20150606
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 29
IP  - 5
DP  - 2015 Jul
TI  - Association of the G1057D polymorphism in insulin receptor substrate 2 gene with 
      type 2 diabetes mellitus: a meta-analysis.
PG  - 731-6
LID - S1056-8727(15)00174-9 [pii]
LID - 10.1016/j.jdiacomp.2015.04.017 [doi]
AB  - OBJECTIVES: The G1057D polymorphism in insulin receptor substrate (IRS)-2 gene is 
      associated with type 2 diabetes mellitus (T2DM) risk, but results in published 
      literatures are controversial. In addition, the effect of obesity as a modifier 
      on this association is also inconsistent. Thus, this meta-analysis was performed 
      to assess the above-mentioned association. METHODS: A comprehensive search was 
      performed to identify case-control or cohort studies (from 1990 to 2014) of the 
      aforementioned association. The I(2) statistic was used to examine between-study 
      heterogeneity. Fixed or random effect model was selected based on heterogeneity 
      test among studies. Publication bias was estimated using modified Egger's 
      regression test. RESULTS: Nine articles with ten studies were included. After 
      excluding studies deviated from Hardy-Weinberg equilibrium (HWE) in controls, 
      results showed a significant association of D allele with reduced T2DM risk in 
      dominant (OR = 0.825, 95% CI: 0.705-0.965) and codominant (OR = 0.857, 95% CI: 
      0.763-0.964) models, but no significant association in recessive (OR = 0.806, 95% 
      CI: 0.628-1.035) model. For studies stratified by obesity, after excluding 
      studies deviated from HWE in controls, no significant association of D allele 
      with T2DM risk was found in three inherited models in obese group; however, a 
      significant protective effect of D allele was observed in dominant (OR = 0.714, 
      95% CI: 0.533-0.958), recessive (OR = 0.438, 95% CI: 0.253-0.760) and codominant 
      (OR = 0.706, 95% CI: 0.565-0.883) models in non-obese group. CONCLUSIONS: This 
      meta-analysis suggested that D allele of G1057D polymorphism have a significant 
      effect on reduced risk of T2DM, and obesity is a modifier of this association. 
      This result needs to be confirmed by further studies.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Jiang, Fan
AU  - Jiang F
AD  - Department of Epidemiology and Biostatistics, Shandong University, P. R. China.
FAU - Li, Suyun
AU  - Li S
AD  - Department of Epidemiology and Biostatistics, Shandong University, P. R. China.
FAU - Pan, Lulu
AU  - Pan L
AD  - Department of Epidemiology and Biostatistics, Shandong University, P. R. China.
FAU - Jia, Chongqi
AU  - Jia C
AD  - Department of Epidemiology and Biostatistics, Shandong University, P. R. China. 
      Electronic address: jiachongqi@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20150428
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (IRS2 protein, human)
RN  - 0 (Insulin Receptor Substrate Proteins)
SB  - IM
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Diabetes Mellitus, Type 2/complications/*genetics/metabolism
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Insulin Receptor Substrate Proteins/*genetics/metabolism
MH  - *Models, Genetic
MH  - Obesity/complications
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Diabetes
OT  - G1057D
OT  - IRS-2
OT  - Meta-analysis
OT  - Polymorphism
EDAT- 2015/05/12 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/05/12 06:00
PHST- 2014/09/29 00:00 [received]
PHST- 2015/03/02 00:00 [revised]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - S1056-8727(15)00174-9 [pii]
AID - 10.1016/j.jdiacomp.2015.04.017 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2015 Jul;29(5):731-6. doi: 
      10.1016/j.jdiacomp.2015.04.017. Epub 2015 Apr 28.