PMID- 25960167
OWN - NLM
STAT- MEDLINE
DCOM- 20151029
LR  - 20181202
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 14
IP  - 9
DP  - 2015 Sep
TI  - Impact of cardiac magnetic resonance imaging on eosinophilic granulomatosis with 
      polyangiitis outcomes: A long-term retrospective study on 42 patients.
PG  - 774-80
LID - S1568-9972(15)00105-6 [pii]
LID - 10.1016/j.autrev.2015.04.013 [doi]
AB  - OBJECTIVE: To determine the diagnostic and prognostic significance of cardiac 
      magnetic resonance imaging (CMRI) in a cohort of patients with eosinophilic 
      granulomatosis with polyangiitis (EGPA). METHODS: We conducted a monocentric 
      retrospective study including 42 EGPA patients who had consecutively undergone 
      CMRI at diagnosis or during follow-up, independently of signs of cardiac 
      involvement. RESULTS: Forty-two patients (male 59.5%, mean age at diagnosis 46.5 
      years) were included. ANCA was positive in 26.2%, and median EGPA duration before 
      the 1st CMRI screening was 5 months. Seventeen (40.5%) were diagnosed with 
      cardiomyopathy, independently of CMRI findings. CMRI showed myocardial late 
      gadolinium enhancement (LGE) in 82.4% patients with cardiomyopathy vs. 44% 
      without cardiomyopathy (P=0.024). Using LGE as the sole criterion, CMRI 
      sensitivity and specificity for diagnosing cardiomyopathy were 82.4% and 56%, 
      respectively. Among the 15 patients with cardiomyopathy who underwent additional 
      CMRI during follow-up, CMRI-detected cardiac lesions had improved in 7 patients, 
      while those of 8 patients worsened or stabilized despite treatment. These latter 
      patients presented with significantly more cardiac events during follow-up 
      (P=0.026). No differences were found between non-cardiomyopathic patients with or 
      without CMRI anomalies concerning EGPA cardiac manifestations and outcomes. 
      CONCLUSION: The diagnostic significance of myocardial LGE in EGPA patients 
      remains uncertain and should not be the only criterion for cardiomyopathy 
      diagnosis. For patients with no other signs of cardiomyopathy, CMRI-detected 
      anomalies do not seem to adversely affect prognosis or outcome. For patients with 
      cardiomyopathy, CMRI reassessment seems promising in detecting patients with a 
      less favorable cardiac outcome.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Dunogue, Bertrand
AU  - Dunogue B
AD  - Department of Internal Medicine, National Referral Center for Rare Systemic and 
      Autoimmune Diseases, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France. Electronic address: 
      bertrand.dunogue@cch.aphp.fr.
FAU - Terrier, Benjamin
AU  - Terrier B
AD  - Department of Internal Medicine, National Referral Center for Rare Systemic and 
      Autoimmune Diseases, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Cohen, Pascal
AU  - Cohen P
AD  - Department of Internal Medicine, National Referral Center for Rare Systemic and 
      Autoimmune Diseases, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Marmursztejn, Julien
AU  - Marmursztejn J
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Legmann, Paul
AU  - Legmann P
AD  - Department of Radiology and Cardiovascular Imaging, Assistance Publique-Hopitaux 
      de Paris, Universite Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Mouthon, Luc
AU  - Mouthon L
AD  - Department of Internal Medicine, National Referral Center for Rare Systemic and 
      Autoimmune Diseases, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Duboc, Denis
AU  - Duboc D
AD  - Department of Cardiology, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Vignaux, Olivier
AU  - Vignaux O
AD  - Department of Radiology and Cardiovascular Imaging, Assistance Publique-Hopitaux 
      de Paris, Universite Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
FAU - Guillevin, Loic
AU  - Guillevin L
AD  - Department of Internal Medicine, National Referral Center for Rare Systemic and 
      Autoimmune Diseases, Assistance Publique-Hopitaux de Paris, Universite 
      Paris-Descartes, Paris 5, Hopital Cochin, Paris, France.
CN  - French Vasculitis Study Group
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150508
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Eosinophils
MH  - Granulomatosis with Polyangiitis/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Cardiomyopathy
OT  - Eosinophilic granulomatosis with polyangiitis
OT  - Prognosis
EDAT- 2015/05/12 06:00
MHDA- 2015/10/30 06:00
CRDT- 2015/05/12 06:00
PHST- 2015/04/25 00:00 [received]
PHST- 2015/04/28 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/10/30 06:00 [medline]
AID - S1568-9972(15)00105-6 [pii]
AID - 10.1016/j.autrev.2015.04.013 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2015 Sep;14(9):774-80. doi: 10.1016/j.autrev.2015.04.013. Epub 
      2015 May 8.