PMID- 25960377
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20161125
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 116
IP  - 2
DP  - 2015 Jul 15
TI  - Effect of gender on results of percutaneous edge-to-edge mitral valve repair with 
      MitraClip system.
PG  - 275-9
LID - S0002-9149(15)01115-7 [pii]
LID - 10.1016/j.amjcard.2015.04.019 [doi]
AB  - Knowledge regarding gender-specific results of percutaneous edge-to-edge mitral 
      valve repair is scarce. The aim of this study was to investigate gender 
      differences in outcomes in a cohort of patients treated with MitraClip 
      implantation. A multicenter registry of 173 patients treated with MitraClip 
      prostheses from 2009 to 2012 at 3 experienced centers was performed. One hundred 
      nine patients (63%) were men. Men were younger (mean age 73 +/- 10 vs 79 +/- 9 years, 
      p = 0.001) and had a higher prevalence of previous coronary bypass graft surgery 
      (34% vs 13%, p = 0.002), previous myocardial infarction (46% vs 20%, p = 0.001), 
      and diabetes mellitus (26% vs 11%, p = 0.020). There were no differences 
      regarding New York Heart Association (NYHA) functional class before the 
      intervention (NYHA class III or IV in 95% of men vs 97% of women, p = 0.472) or 
      the cause of mitral regurgitation (MR) (functional in 58% of men vs 48% of women, 
      p = 0.233). Men exhibited significantly larger ventricles (mean indexed left 
      ventricular end-systolic diameter 2.4 +/- 0.8 vs 2.0 +/- 1.6 cm/m(2), p = 0.002, and 
      mean indexed left ventricular end-diastolic volume 92.7 +/- 46.1 vs 59.9 +/- 24.6 
      ml/m(2), p <0.001). At 1 month, there were no differences between groups in the 
      reduction of MR or NYHA functional class (MR grade </=2+ in 98.2% of men vs 96.8% 
      of women, p = 0.586, and NYHA class </=II in 78.3% of men vs 77% of women, p = 
      0.851). At 6 months, results were maintained (MR grade </=2+ in 89.5% of men vs 
      96.8% of women, p = 0.414, and NYHA class </=II in 73.1% of men vs 74.2% of women, 
      p = 0.912). After a mean follow-up period of 16.1 +/- 11.1 months, no difference 
      was found between groups in the incidence of death or admission for heart failure 
      (log-rank p = 0.798). In conclusion, MitraClip implantation seems to be an 
      equally safe and effective treatment of MR in men and women.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Estevez-Loureiro, Rodrigo
AU  - Estevez-Loureiro R
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom. 
      Electronic address: roiestevez@hotmail.com.
FAU - Settergren, Magnus
AU  - Settergren M
AD  - Unit for Interventional Cardiology, Department of Cardiology, Karolinska 
      University Hospital and Karolinska Institutet, Stockholm, Sweden.
FAU - Winter, Reidar
AU  - Winter R
AD  - Unit for Interventional Cardiology, Department of Cardiology, Karolinska 
      University Hospital and Karolinska Institutet, Stockholm, Sweden.
FAU - Jacobsen, Per
AU  - Jacobsen P
AD  - Unit for Interventional Cardiology, Department of Cardiology, Karolinska 
      University Hospital and Karolinska Institutet, Stockholm, Sweden.
FAU - Dall'Ara, Gianni
AU  - Dall'Ara G
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Sondergaard, Lars
AU  - Sondergaard L
AD  - Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Cheung, Gary
AU  - Cheung G
AD  - Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Pighi, Michele
AU  - Pighi M
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Ghione, Matteo
AU  - Ghione M
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Ihlemann, Nikolaj
AU  - Ihlemann N
AD  - Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Moat, Neil E
AU  - Moat NE
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Price, Susanna
AU  - Price S
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Streit Rosenberg, Tine
AU  - Streit Rosenberg T
AD  - Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
FAU - Di Mario, Carlo
AU  - Di Mario C
AD  - Department of Cardiology, National Institute Health Research Cardiovascular 
      Biomedical Research Unit, Royal Brompton Hospital, London, United Kingdom.
FAU - Franzen, Olaf
AU  - Franzen O
AD  - Division of Cardiology, Rigshospitalet, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20150418
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Denmark/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Mitral Valve Insufficiency/mortality/*surgery
MH  - Postoperative Complications/*epidemiology
MH  - Prosthesis Design
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Survival Rate/trends
MH  - Sweden/epidemiology
MH  - Treatment Outcome
MH  - United Kingdom/epidemiology
EDAT- 2015/05/12 06:00
MHDA- 2015/08/26 06:00
CRDT- 2015/05/12 06:00
PHST- 2015/02/19 00:00 [received]
PHST- 2015/04/09 00:00 [revised]
PHST- 2015/04/09 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
AID - S0002-9149(15)01115-7 [pii]
AID - 10.1016/j.amjcard.2015.04.019 [doi]
PST - ppublish
SO  - Am J Cardiol. 2015 Jul 15;116(2):275-9. doi: 10.1016/j.amjcard.2015.04.019. Epub 
      2015 Apr 18.