PMID- 25960616
OWN - NLM
STAT- MEDLINE
DCOM- 20160201
LR  - 20181113
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - Decrease in circulating dendritic cell precursors in patients with peripheral 
      artery disease.
PG  - 450957
LID - 10.1155/2015/450957 [doi]
LID - 450957
AB  - Peripheral artery disease (PAD) is a common manifestation of atherosclerosis. 
      Inflammation is important for initiation and progression of the disease. 
      Dendritic cells (DCs) as antigen-presenting cells play an important role in the 
      immune system. Therefore, we hypothesize that, in patients with PAD, DCPs might 
      be reduced in blood due to their recruitment into the vascular wall and induce a 
      proinflammatory response. The numbers of myeloid DCPs, plasmacytoid DCPs, and 
      total DCPs were analyzed by flow cytometry in blood of patients with PAD (n = 52) 
      compared to controls (n = 60). Femoralis plaques (n = 12) of patients who 
      underwent surgery were immunostained for CD209 and CD83 (mDCs) as well as CD304, 
      CD123 (pDCs), and HLA-DR. In patients with PAD, a significant decrease in mDCPs, 
      pDCPs, and tDCPs was observed. In immunostaining, markers indicative for mDCs 
      (CD209: 16 versus 8 cells/0.1 mm(2), P = 0.02; CD83: 19 versus 5 cells/0.1 mm(2), 
      P = 0.03) were significantly elevated in femoralis plaques compared to control 
      vessels. We show for the first time that mDCPs, pDCPs, and tDCPs are 
      significantly reduced in patients with PAD. Immunohistochemical analysis 
      unraveled that the decrease in DCPs might be due to their recruitment into 
      atherosclerotic plaques.
FAU - Kretzschmar, Daniel
AU  - Kretzschmar D
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Rohm, Ilonka
AU  - Rohm I
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Schaller, Sebastian
AU  - Schaller S
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Betge, Stefan
AU  - Betge S
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Pistulli, Rudin
AU  - Pistulli R
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Atiskova, Yevgeniya
AU  - Atiskova Y
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Figulla, Hans-R
AU  - Figulla HR
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
FAU - Yilmaz, Atilla
AU  - Yilmaz A
AD  - Department of Internal Medicine I, Jena University Hospital, 
      Friedrich-Schiller-University Jena, Erlanger Allee 101, 07740 Jena, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150415
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/blood
MH  - Case-Control Studies
MH  - Cell Separation
MH  - Dendritic Cells/*cytology
MH  - Echocardiography
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation/immunology
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/cytology
MH  - Peripheral Arterial Disease/blood/*immunology
MH  - Plaque, Atherosclerotic/immunology
PMC - PMC4413958
EDAT- 2015/05/12 06:00
MHDA- 2016/02/02 06:00
PMCR- 2015/04/15
CRDT- 2015/05/12 06:00
PHST- 2014/11/03 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/02/02 06:00 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
AID - 10.1155/2015/450957 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:450957. doi: 10.1155/2015/450957. Epub 2015 Apr 15.