PMID- 25960857
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150511
LR  - 20200930
IS  - 2035-3006 (Print)
IS  - 2035-3006 (Electronic)
IS  - 2035-3006 (Linking)
VI  - 7
IP  - 1
DP  - 2015
TI  - Is the incidence trend of heparin-induced thrombocytopenia decreased by the 
      increased use of low-molecular-weight-heparin?
PG  - e2015029
LID - 10.4084/MJHID.2015.029 [doi]
LID - e2015029
AB  - BACKGROUND: The increasing trend of using low-molecular-weight-heparin (LMWH) 
      versus unfractionated heparin (UFH) in hospitalized adult patients is raising 
      concerns about the incidence of heparin-induced thrombocytopenia (HIT). METHOD: A 
      retrospective study analyzed the requests for heparin-induced antibodies by 
      enzyme-linked immunosorbent assay (ELISA) among adult hospitalized patients 
      during the period from January 2011 to December 2013. These patients received 
      either UFH or LMWH for prevention or therapeutic indications. Those with positive 
      immune-mediated HIT were identified and considered as case patients. RESULT: The 
      usage of LMWH and UFH and development of HIT was determined during the study 
      period. The incidence of HIT in patients receiving UFH and those receiving LMWH 
      was 4.09 per thousand patients and 0.48 per thousand patients, respectively, 
      (p<0.0001) with an overall incidence of 2.49 per thousand patients. CONCLUSION: 
      The increased trend of using LMWH over UFH among hospitalized adult patients was 
      observed and can be said to contribute to the diminished overall incidence of 
      HIT.
FAU - Al-Eidan, Fahad A S
AU  - Al-Eidan FA
AD  - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, 
      Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20150420
PL  - Italy
TA  - Mediterr J Hematol Infect Dis
JT  - Mediterranean journal of hematology and infectious diseases
JID - 101530512
PMC - PMC4418371
EDAT- 2015/05/12 06:00
MHDA- 2015/05/12 06:01
PMCR- 2015/01/01
CRDT- 2015/05/12 06:00
PHST- 2015/01/18 00:00 [received]
PHST- 2015/03/13 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/05/12 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - mjhid-7-1-e2015029 [pii]
AID - 10.4084/MJHID.2015.029 [doi]
PST - epublish
SO  - Mediterr J Hematol Infect Dis. 2015 Apr 20;7(1):e2015029. doi: 
      10.4084/MJHID.2015.029. eCollection 2015.