PMID- 25960950
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150511
LR  - 20200930
IS  - 2233-6834 (Print)
IS  - 2233-6842 (Electronic)
IS  - 2233-6834 (Linking)
VI  - 19
IP  - 1
DP  - 2015 Mar
TI  - Treadmill exercise after social isolation increases the levels of NGF, BDNF, and 
      synapsin I to induce survival of neurons in the hippocampus, and improves 
      depression-like behavior.
PG  - 11-8
LID - 10.5717/jenb.2015.19.1.11 [doi]
AB  - PURPOSE: We investigated the effects of 8 weeks of treadmill exercise on nerve 
      growth factor (NGF), brain-derived neurotrophic factor (BDNF), and synapsin I 
      protein expression and on the number of 5-bromo-2'-deoxyuridine-5'-mono-phosphate 
      (BrdU)-positive cells in the dentate gyrus of the hippocampus in socially 
      isolated rats. Additionally, we examined the effects of exercise on the number of 
      serotonin (5-HT)- and tryptophan hydroxylase (TPH)-positive cells in the raphe 
      nuclei and on depression behaviors induced by social isolation. METHODS: Forty 
      male Sprague-Dawley rats were divided into four groups: (1) group housing and 
      control group (GCG, n = 10); (2) group housing and exercise group (GEG, n = 10); 
      (3) isolated housing and control group (ICG, n = 10); and (4) isolated housing 
      and exercise group (IEG, n = 10). After 1 week of housing under the normal 
      condition of 3 animals per cage, rats were socially isolated via transfer to 
      individual cages for 8 weeks. Rats were then subjected to treadmill exercise for 
      5 days per week for 8 weeks during which time the speed of the treadmill was 
      gradually increased. RESULTS: Compared to the GCG, levels of NGF, BDNF, and 
      synapsin I were significantly decreased in the ICG and significantly increased in 
      the IEG (p < 0.001 respectively). Significantly more BrdU-positive cells in the 
      GEG were present as compared to the GCG and ICG, and more BrdU-positive cells 
      were found in the IEG as compared to the ICG (p < 0.001). 5-HT-positive cells in 
      the GEG were significantly increased compared to the GCG and ICG, and more of 
      these cells were found in the IEG as compared to the ICG (p < 0.01). TPH-positive 
      cells in the GEG were significantly increased compared to those in the GCG and 
      ICG (p < 0.05). In the forced swim test, immobility time was significantly 
      increased in the ICG and significantly decreased in the IEG as compared to the 
      ICG (p < 0.01). CONCLUSION: These results showed that regular treadmill exercise 
      following social isolation not only increased the levels of NGF, BDNF, and 
      synapsin I to induce survival of neurons in the hippocampus but also improved 
      depression by increasing the number of serotonergic cells in the raphe nuclei.
FAU - Hong, Young-Pyo
AU  - Hong YP
AD  - Department of Health and Sport Science, Korea National Sport University, Seoul, 
      Korea.
FAU - Lee, Hyo-Chul
AU  - Lee HC
AD  - Department of Health and Sport Science, Korea National Sport University, Seoul, 
      Korea.
FAU - Kim, Hyun-Tae
AU  - Kim HT
AD  - Department of Health and Sport Science, Korea National Sport University, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20150331
PL  - Korea (South)
TA  - J Exerc Nutrition Biochem
JT  - Journal of exercise nutrition & biochemistry
JID - 101572566
PMC - PMC4424441
OTO - NOTNLM
OT  - Nerve growth factor
OT  - brain-derived neurotrophic factor
OT  - serotonin
OT  - synapsin I
OT  - treadmill exercise
OT  - tryptophan hydroxylase
EDAT- 2015/05/12 06:00
MHDA- 2015/05/12 06:01
PMCR- 2015/03/01
CRDT- 2015/05/12 06:00
PHST- 2015/01/16 00:00 [received]
PHST- 2015/02/01 00:00 [revised]
PHST- 2015/02/05 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/05/12 06:01 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - jenb-19-1-11 [pii]
AID - 10.5717/jenb.2015.19.1.11 [doi]
PST - ppublish
SO  - J Exerc Nutrition Biochem. 2015 Mar;19(1):11-8. doi: 10.5717/jenb.2015.19.1.11. 
      Epub 2015 Mar 31.