PMID- 25960980
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150511
LR  - 20200930
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 11
IP  - 2
DP  - 2015 Apr
TI  - Treadmill exercise prevents GABAergic neuronal loss with suppression of neuronal 
      activation in the pilocarpine-induced epileptic rats.
PG  - 80-6
LID - 10.12965/jer.150193 [doi]
AB  - Epilepsy is a common neurological disorder characterized by seizure and loss of 
      neuronal cells by abnormal rhythmic firing of neurons in the brain. In the 
      present study, we investigated the effect of treadmill exercise on 
      gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal 
      activation using pilocarpine-induced epileptic rats. The rats were divided into 
      four groups: control group, control and treadmill exercise group, 
      pilocarpine-induced epilepsy group, and pilocarpine-induced epilepsy and 
      treadmill exercise group. Epilepsy was induced by intraperitoneal injection of 
      320 mg/kg pilocarpine hydrochloride. The rats in the exercise groups were forced 
      to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present 
      results, neuronal loss in the hippocampal CA1 region was increased after 
      pilocarpine-induced seizure. Treadmill exercise inhibited hippocampal neuronal 
      loss in the epileptic rats. Glutamic acid decarboxylase (GAD67) expression in the 
      hippocampal CA1 region was reduced by pilocarpine-induced seizure. Treadmill 
      exercise increased GAD67 expression in the epileptic rats. c-Fos expression in 
      the hippocampal CA1 region was increased in response to epileptic seizure. 
      Treadmill exercise inhibited c-Fos expression in the epileptic rats. Epileptic 
      seizure increased brain-derived neurotrophic factor (BDNF) and tyrosine kinase 
      receptor B (TrkB) expressions in the hippocampus. Treadmill exercise suppressed 
      BDNF and TrkB expressions in the epileptic rats. In the present study, treadmill 
      exercise prevented GABAergic neuronal loss and inhibited neuronal activation in 
      the hippocampal CA1 region through the down-regulation of BDNF-TrkB signaling 
      pathway.
FAU - Lim, Baek-Vin
AU  - Lim BV
AD  - Department of Exercise Prescription, Division of Leisure & Sports Science, 
      Dongseo University, Busan, Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Lee, Jae-Min
AU  - Lee JM
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Seo, Jin-Hee
AU  - Seo JH
AD  - Division of Sports Science, Baekseok University, Cheonan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150430
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4415754
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Epilepsy
OT  - Glutamic acid decarboxylase
OT  - Treadmill exercise
OT  - Tyrosine kinase receptor B
OT  - c-Fos
EDAT- 2015/05/12 06:00
MHDA- 2015/05/12 06:01
PMCR- 2015/04/30
CRDT- 2015/05/12 06:00
PHST- 2015/03/22 00:00 [received]
PHST- 2015/04/08 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2015/05/12 06:01 [medline]
PHST- 2015/04/30 00:00 [pmc-release]
AID - jer-11-2-80 [pii]
AID - 10.12965/jer.150193 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2015 Apr 30;11(2):80-6. doi: 10.12965/jer.150193. eCollection 
      2015 Apr.