PMID- 25961231
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150513
LR  - 20150512
IS  - 1868-1883 (Print)
IS  - 1868-1883 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Dec 1
TI  - Protective effect of estrogens on the brain of rats with essential and endocrine 
      hypertension.
PG  - 549-57
LID - /j/hmbci.2010.4.issue-2/hmbci.2010.044/hmbci.2010.044.xml [pii]
LID - 10.1515/HMBCI.2010.044 [doi]
AB  - Estrogen neuroprotection has been shown in pathological conditions damaging the 
      hippocampus, such as trauma, aging, neurodegeneration, excitotoxicity, oxidative 
      stress, hypoglycemia, amyloid-beta peptide exposure and ischemia. Hypertensive 
      encephalopathy also targets the hippocampus; therefore, hypertension seems an 
      appropriate circumstance to evaluate steroid neuroprotection. Two experimental 
      models of hypertension, spontaneously hypertensive rats (SHR) and 
      deoxycorticosterone (DOCA)-salt hypertensive rats, develop hippocampal 
      abnormalities, which include decreased neurogenesis in the dentate gyrus, 
      astrogliosis, low expression of brain-derived neurotrophic factor (BDNF) and 
      decreased number of neurons in the hilar region, with respect of their 
      normotensive strains Wistar Kyoto (WKY) and Sprague-Dawley rats. After estradiol 
      was given for 2 weeks to SHR and DOCA-treated rats, both hypertensive models 
      normalized their faulty hippocampal parameters. Thus, estradiol treatment 
      positively modulated neurogenesis in the dentate gyrus of the hippocampus, 
      according to bromodeoxyuridine incorporation and doublecortin 
      immunocytochemistry, decreased reactive astrogliosis, increased BDNF mRNA and 
      protein expression in the dentate gyrus and increased neuronal number in the 
      hilar region of the dentate gyrus. A role of local estrogen biosynthesis is 
      suggested in SHR, because basal aromatase mRNA in the hippocampus and 
      immunoreactive aromatase protein in cell processes of the dentate gyrus were 
      highly expressed in these rats. Estradiol further stimulated aromatase-related 
      parameters in SHR but not in WKY. These observations strongly support that a 
      combination of exogenous estrogens to those locally synthesized might better 
      alleviate hypertensive encephalopathy. These studies broaden estrogen 
      neuroprotective functions to the hippocampus of hypertensive rat models.
FAU - De Nicola, Alejandro F
AU  - De Nicola AF
FAU - Pietranera, Luciana
AU  - Pietranera L
FAU - Bellini, Maria Jose
AU  - Bellini MJ
FAU - Goya, Rodolfo
AU  - Goya R
FAU - Brocca, Maria Elvira
AU  - Brocca ME
FAU - Garcia-Segura, Luis Miguel
AU  - Garcia-Segura LM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Horm Mol Biol Clin Investig
JT  - Hormone molecular biology and clinical investigation
JID - 101538885
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2015/05/12 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2015/05/12 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - /j/hmbci.2010.4.issue-2/hmbci.2010.044/hmbci.2010.044.xml [pii]
AID - 10.1515/HMBCI.2010.044 [doi]
PST - ppublish
SO  - Horm Mol Biol Clin Investig. 2010 Dec 1;4(2):549-57. doi: 10.1515/HMBCI.2010.044.