PMID- 25961538
OWN - NLM
STAT- MEDLINE
DCOM- 20160324
LR  - 20220223
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 20
IP  - 6
DP  - 2015 Jun 1
TI  - L-arginine improves DNA synthesis in LPS-challenged enterocytes.
PG  - 989-1003
AB  - The neonatal small intestine is susceptible to damage by endotoxin, and this 
      cytotoxicity may involve intracellular generation of reactive oxygen species 
      (ROS), resulting in DNA damage and mitochondrial dysfunction. L-Arginine (Arg) 
      confers a cytoprotective effect on lipopolysaccharide (LPS)-treated enterocytes 
      through activation of the mammalian target of the rapamycin (mTOR) signaling 
      pathway. Arg improves DNA synthesis and mitochondrial bioenergetics, which may 
      also be responsible for beneficial effects of Arg on intestinal mucosal cells. In 
      support of this notion, results of recent studies indicate that elevated Arg 
      concentrations enhances DNA synthesis, cell-cycle progression, and mitochondrial 
      bioenergetics in LPS-treated intestinal epithelial cells through mechanisms 
      involving activation of the PI3K-Akt pathway. These findings provide a 
      biochemical basis for dietary Arg supplementation to improve the regeneration and 
      repair of the small-intestinal mucosa in both animals and humans.
FAU - Tan, Bi'e
AU  - Tan B
AD  - Observation and Experiment Station of Animal Nutrition and Feed Science in 
      South-Central China, Ministry of Agriculture; Hunan Provincial Engineering 
      Research Center for Healthy Livestock and Poultry Production, Key Laboratory of 
      Agro-ecological Processes, bietan@isa.ac.cn.
FAU - Xiao, Hao
AU  - Xiao H
FAU - Xiong, Xia
AU  - Xiong X
FAU - Wang, Jing
AU  - Wang J
FAU - Li, Guangran
AU  - Li G
FAU - Yin, Yulong
AU  - Yin Y
FAU - Huang, Bo
AU  - Huang B
FAU - Hou, Yongqing
AU  - Hou Y
FAU - Wu, Guoyao
AU  - Wu G
AD  - Department of Animal Science, Texas A&M University.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150601
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-49-2 (DNA)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Animals
MH  - Arginine/*pharmacology
MH  - DNA/*biosynthesis
MH  - Energy Metabolism
MH  - Enterocytes/*cytology/drug effects/metabolism
MH  - Mitochondria/drug effects/physiology
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/drug effects
MH  - Swine
EDAT- 2015/05/12 06:00
MHDA- 2016/03/25 06:00
CRDT- 2015/05/12 06:00
PHST- 2015/05/12 06:00 [entrez]
PHST- 2015/05/12 06:00 [pubmed]
PHST- 2016/03/25 06:00 [medline]
AID - 4352 [pii]
AID - 10.2741/4352 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2015 Jun 1;20(6):989-1003. doi: 10.2741/4352.